Biochemistry (Moscow)

, Volume 77, Issue 7, pp 761–775

Phenoptosis in yeasts

  • E. I. Sukhanova
  • A. G. Rogov
  • F. F. Severin
  • R. A. Zvyagilskaya
Review

DOI: 10.1134/S0006297912070097

Cite this article as:
Sukhanova, E.I., Rogov, A.G., Severin, F.F. et al. Biochemistry Moscow (2012) 77: 761. doi:10.1134/S0006297912070097

Abstract

The current view on phenoptosis and apoptosis as genetic programs aimed at eliminating potentially dangerous organisms and cells, respectively, is given. Special emphasis is placed on apoptosis (phenoptosis) in yeasts: intracellular defects and a plethora of external stimuli inducing apoptosis in yeasts; distinctive morphological and biochemical hallmarks accompanying apoptosis in yeasts; pro- and antiapoptotic factors involved in yeast apoptosis signaling; consecutive stages of apoptosis from external stimulus to the cell death; a prominent role of mitochondria and other organelles in yeast apoptosis; possible pathways for release of apoptotic factors from the intermembrane mitochondrial space into the cytosol are described. Using some concrete examples, the obvious physiological importance and expediency of altruistic death of yeast cells is shown. Poorly known aspects of yeast apoptosis and prospects for yeast apoptosis study are defined.

Key words

yeastsphenoptosisapoptosismitochondriaendoplasmic reticulumvacuole

Abbreviations

AIF

apoptosis inducing factor

AMID

AIF-homologous mitochondrion-associated inducer of death

CsA

cyclosporin A

ER

endoplasmic reticulum

HtrA

located in the intermembrane space high temperature required protease A

IAP

protein, inhibitor of apoptosis

mPTP (mitochondrial permeability transition pore)

nonspecific permeability of the inner mitochondrial membrane

OST

oligosaccharyl transferase

Pi

inorganic phosphate

ROS

reactive oxygen species

SOD

superoxide dismutase

YMUC

yeast mitochondrial unspecific channel

Ysp1p and Ysp2p

mitochondrial yeast suicide proteins

Copyright information

© Pleiades Publishing, Ltd. 2012

Authors and Affiliations

  • E. I. Sukhanova
    • 1
  • A. G. Rogov
    • 1
  • F. F. Severin
    • 2
  • R. A. Zvyagilskaya
    • 1
  1. 1.Bach Institute of BiochemistryRussian Academy of SciencesMoscowRussia
  2. 2.Belozersky Institute of Physico-Chemical BiologyLomonosov Moscow State UniversityMoscowRussia