Biochemistry (Moscow)

, Volume 77, Issue 2, pp 128–134

NMDA receptors in immune competent cells

Authors

    • International Biotechnological CenterLomonosov Moscow State University
    • Laboratory of Clinical Neurochemistry, Research Center of NeurologyRussian Academy of Medical Sciences
  • E. A. Bryushkova
    • International Biotechnological CenterLomonosov Moscow State University
  • E. A. Vladychenskaya
    • International Biotechnological CenterLomonosov Moscow State University
Review

DOI: 10.1134/S0006297912020022

Cite this article as:
Boldyrev, A.A., Bryushkova, E.A. & Vladychenskaya, E.A. Biochemistry Moscow (2012) 77: 128. doi:10.1134/S0006297912020022

Abstract

This review presents analysis of literature data indicating the presence of NMDA-type glutamate receptors in several types of immune competent cells such as thymocytes, lymphocytes, and neutrophils. The possible role of these receptors in the function of these cells is discussed. The interaction of the receptors with certain ligands circulating in the blood-stream and their role in modulation of immune function is described. It is suggested that homocysteine acts as modulator of these receptors, and its toxicity is largely explained by hyperactivation of the NMDA-type glutamate receptors.

Key words

NMDA receptorslymphocytesneutrophilsthymocytes

Abbreviations

HC

homocysteine

HCA

homocysteic acid

MPO

myeloperoxidase

NMDA

N-methyl-D-aspartate

ROS

reactive oxygen species

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Copyright information

© Pleiades Publishing, Ltd. 2012