Biochemistry (Moscow)

, Volume 76, Issue 4, pp 467–472

Effect of homocysteine on properties of neutrophils activated in vivo

  • E. A. Bryushkova
  • E. A. Vladychenskaya
  • M. S. Stepanova
  • A. A. Boldyrev
Article

DOI: 10.1134/S0006297911040109

Cite this article as:
Bryushkova, E.A., Vladychenskaya, E.A., Stepanova, M.S. et al. Biochemistry Moscow (2011) 76: 467. doi:10.1134/S0006297911040109

Abstract

We have found that neutrophils begin to express NMDA receptors on their membranes after in vivo activation. These receptors are the target for action of homocysteine (HC). After incubation of activated neutrophils with HC, the degranulation process is stimulated and generation of reactive oxygen species is increased. We conclude that expression of NMDA receptors on neutrophil membrane makes neutrophils sensitive to HC. Thus, hyperhomocysteinemia may induce additional stimulation of immune competent cells.

Key words

neutrophilsinflammationNMDA receptorshomocysteine

Abbreviations

HC

homocysteine

ROS

reactive oxygen species

Copyright information

© Pleiades Publishing, Ltd. 2011

Authors and Affiliations

  • E. A. Bryushkova
    • 1
    • 2
  • E. A. Vladychenskaya
    • 1
  • M. S. Stepanova
    • 2
  • A. A. Boldyrev
    • 1
    • 2
  1. 1.Biological FacultyLomonosov Moscow State UniversityMoscowRussia
  2. 2.Laboratory of Clinical Neurochemistry, Research Center of NeurologyRussian Academy of Medical SciencesMoscowRussia