Biochemistry (Moscow)

, Volume 75, Issue 8, pp 951–958

Renalase, a new secretory enzyme responsible for selective degradation of catecholamines: Achievements and unsolved problems

Authors

    • Institute of Biomedical ChemistryRussian Academy of Medical Sciences
  • A. V. Veselovsky
    • Institute of Biomedical ChemistryRussian Academy of Medical Sciences
  • V. I. Fedchenko
    • Institute of Biomedical ChemistryRussian Academy of Medical Sciences
Review

DOI: 10.1134/S0006297910080018

Cite this article as:
Medvedev, A.E., Veselovsky, A.V. & Fedchenko, V.I. Biochemistry Moscow (2010) 75: 951. doi:10.1134/S0006297910080018

Abstract

Renalase is a recently discovered secretory enzyme responsible for selective degradation of blood catecholamines. The review summarizes literature data on expression of this enzyme and on its structure and functions. Special attention is paid to unsolved and questionable problems including: 1) prediction of the presence of FAD in the protein structure based on amino acid sequence similarity of renalase with known FAD-dependent enzymes; 2) identity of plasma and urinary renalase; 3) mechanism underlying conversion of inactive renalase into the active form.

Key words

catecholamines enzymatic degradation renalase structure function bioinformation analysis of amino acid sequence

Copyright information

© Pleiades Publishing, Ltd. 2010