Biochemistry (Moscow)

, Volume 75, Issue 7, pp 811–824

“Smart” liposomal nanocontainers in biology and medicine

Authors

    • Institute of Theoretical and Experimental BiophysicsRussian Academy of Sciences
Review

DOI: 10.1134/S0006297910070023

Cite this article as:
Tarahovsky, Y.S. Biochemistry Moscow (2010) 75: 811. doi:10.1134/S0006297910070023

Abstract

The perspectives of using liposomes for delivery of drugs to desired parts of the human body have been intensively investigated for more than 30 years. During this time many inventions have been suggested and different kinds of liposomal devices developed, and a number of them have reached the stages of preclinical or clinical trials. The latest techniques can be used to develop biocompatible nano-sized liposomal containers having some abilities of artificial intellect, such as the presence of sensory and responsive units. However, only a few have been clinically approved. Further improvements in this area depend on our knowledge of the interactions of drugs with the lipid bilayer of liposomes. Further studies on liposomal transport through the human body, their targeting of cells requiring therapeutic treatment, and finally, the development of techniques for controlled drug delivery to desired acceptors on cell surfaces or in cytoplasm are still required.

Key words

liposomesintellectual nanocontainersdrugs targetingnanomedicine

Abbreviations

CHEMS

cholesteryl hemisuccinate

DOPE

dioleoyl phosphatidylethanolamine

DPPC

dipalmitoyl phosphatidylcholine

DSPC

distearoyl phosphatidylcholine

EPR

enhanced permeability and retention

FR

folate receptor

HePC

hexadecyl phosphocholine

IR

infrared light

OA

oleic acid

PA

phosphatidic acid

PC

phosphatidylcholine

PE

phosphatidylethanolamine

PEG

polyethyleneglycol

PS

phosphatidylserine

RES

reticuloendothelial system

RFC

reduced folate carrier

UV

ultraviolet light

Copyright information

© Pleiades Publishing, Ltd. 2010