Biochemistry (Moscow)

, Volume 75, Issue 3, pp 281–296

Oxidative stress in yeast

Review

DOI: 10.1134/S0006297910030041

Cite this article as:
Lushchak, V.I. Biochemistry Moscow (2010) 75: 281. doi:10.1134/S0006297910030041
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Abstract

The mechanisms of production and elimination of reactive oxygen species in the cells of the budding yeast Saccharomyces cerevisiae are analyzed. Coordinative role of special regulatory proteins including Yap1p, Msn2/4p, and Skn7p (Pos9p) in regulation of defense mechanisms in S. cerevisiae is described. A special section is devoted to two other well-studied species from the point of view of oxidative stress — Schizosaccharomyces pombe and Candida albicans. Some examples demonstrating the use of yeast for investigation of apoptosis, aging, and some human diseases are given in the conclusion part.

Key words

yeast Saccharomyces cerevisiae Schizosaccharomyces pombe Candida albicans oxidative stress response regulatory proteins 

Abbreviations

AMT

aminotriazole

cAMP-PKA

cAMP-dependent protein kinase A

DDC

diethyldithiocarbamate

G6PDH

glucose-6-phosphate dehydrogenase

ROS

reactive oxygen species

SOD

superoxide dismutase

Copyright information

© Pleiades Publishing, Ltd. 2010

Authors and Affiliations

  1. 1.Department of BiochemistryVassyl Stefanyk Precarpathian National UniversityIvano-FrankivskUkraine

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