Biochemistry (Moscow)

, Volume 74, Issue 3, pp 235–249

Ganglioside GM3 and its biological functions

Authors

    • Institute of Experimental Cardiology, Russian Cardiology Research CenterRussian Ministry of Health
  • N. N. Samovilova
    • Institute of Experimental Cardiology, Russian Cardiology Research CenterRussian Ministry of Health
  • E. V. Gracheva
    • Institute of Experimental Cardiology, Russian Cardiology Research CenterRussian Ministry of Health
  • N. K. Golovanova
    • Institute of Experimental Cardiology, Russian Cardiology Research CenterRussian Ministry of Health
Review

DOI: 10.1134/S0006297909030018

Cite this article as:
Prokazova, N.V., Samovilova, N.N., Gracheva, E.V. et al. Biochemistry Moscow (2009) 74: 235. doi:10.1134/S0006297909030018

Abstract

Metabolism, topology, and possible mechanisms for regulation of the ganglioside GM3 content in the cell are reviewed. Under consideration are biological functions of GM3, such as involvement in cell differentiation, proliferation, oncogenesis, and apoptosis.

Key words

ganglioside GM3GM3 synthasemetabolismcell differentiationproliferationoncogenesisapoptosis

Abbreviations

CDK

cyclin-dependent kinase

Cer

ceramide

CRE

cAMP-responsive element

CREB

CRE-binding protein

DIM

detergent-insoluble material

EGF

epidermal growth factor

ERK

extracellularly regulated protein kinase

FAK

focal adhesion kinase

FGF

fibroblast growth factor

Gal

galactose

GEM

ganglioside-enriched microdomains

Glc

glucose

GPI

glycosyl phosphatidyl inositol

LacCer

lactosylceramide

MAPK

mitogen-activated protein kinase

Neu3

plasma membrane sialidase

NeuAc (SA)

N-acetylneuraminic (sialic) acid

PDGF

platelet-derived growth factor

PDMP

D-1-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol

PI3K

phosphatidylinositol-3 kinase

PKA, PKB/Akt, and PKC

protein kinase A, B/Akt, and C, respectively

PPPP

D-1-threo-1-phenyl-2-palmitoylamino-3-pyrrolidino-1-propanol

SAP

saposin

TNF-α

tumor necrosis factor-α

VEGF

vascular endothelial growth factor

Copyright information

© Pleiades Publishing, Ltd. 2009