Review

Biochemistry (Moscow)

, Volume 74, Issue 3, pp 235-249

First online:

Ganglioside GM3 and its biological functions

  • N. V. ProkazovaAffiliated withInstitute of Experimental Cardiology, Russian Cardiology Research Center, Russian Ministry of Health Email author 
  • , N. N. SamovilovaAffiliated withInstitute of Experimental Cardiology, Russian Cardiology Research Center, Russian Ministry of Health
  • , E. V. GrachevaAffiliated withInstitute of Experimental Cardiology, Russian Cardiology Research Center, Russian Ministry of Health
  • , N. K. GolovanovaAffiliated withInstitute of Experimental Cardiology, Russian Cardiology Research Center, Russian Ministry of Health

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Abstract

Metabolism, topology, and possible mechanisms for regulation of the ganglioside GM3 content in the cell are reviewed. Under consideration are biological functions of GM3, such as involvement in cell differentiation, proliferation, oncogenesis, and apoptosis.

Key words

ganglioside GM3 GM3 synthase metabolism cell differentiation proliferation oncogenesis apoptosis