Biochemistry (Moscow)

, Volume 73, Issue 13, pp 1388–1404

Mechanisms of single-stranded DNA-binding protein functioning in cellular DNA metabolism

Authors

  • P. E. Pestryakov
    • Institute of Chemical Biology and Fundamental MedicineSiberian Branch of the Russian Academy of Sciences
    • Institute of Chemical Biology and Fundamental MedicineSiberian Branch of the Russian Academy of Sciences
Review

DOI: 10.1134/S0006297908130026

Cite this article as:
Pestryakov, P.E. & Lavrik, O.I. Biochemistry Moscow (2008) 73: 1388. doi:10.1134/S0006297908130026

Abstract

This review deals with analysis of mechanisms involved in coordination of DNA replication and repair by SSB proteins; characteristics of eukaryotic, prokaryotic, and archaeal SSB proteins are considered, which made it possible to distinguish general mechanisms specific for functioning of proteins from organisms of different life domains. Mechanisms of SSB protein interactions with DNA during metabolism of the latter are studied; structural organization of the SSB protein complexes with DNA, as well as structural and functional peculiarities of different SSB proteins are analyzed.

Key words

SSB proteinsreplication protein Aprotein-DNA complexesDNA replicationDNA repair

Abbreviations

a.a.

amino acid residues

dsDNA

double-stranded DNA

ecoSSB

Escherichia coli SSB

hsRPA

Homo sapiens RPA

NER

nucleotide excision repair

nt

nucleotide

OB domain

oligosaccharide/oligonucleotide-binding domain

PCNA

proliferating cell nuclear antigen

pol-prim

DNA polymerase α-primase complex

RFC

replication factor C

RPA

replication protein A

SSB

single-stranded DNA-binding protein

ssDNA

single-stranded DNA

Copyright information

© MAIK Nauka 2008