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Mitochondria-targeted plastoquinone derivatives as tools to interrupt execution of the aging program. 5. SkQ1 prolongs lifespan and prevents development of traits of senescence

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Abstract

Very low (nano- and subnanomolar) concentrations of 10-(6′-plastoquinonyl) decyltriphenylphosphonium (SkQ1) were found to prolong lifespan of a fungus (Podospora anserina), a crustacean (Ceriodaphnia affinis), an insect (Drosophila melanogaster), and a mammal (mouse). In the latter case, median lifespan is doubled if animals live in a non-sterile vivarium. The lifespan increase is accompanied by rectangularization of the survival curves (an increase in survival is much larger at early than at late ages) and disappearance of typical traits of senescence or retardation of their development. Data summarized here and in the preceding papers of this series suggest that mitochondria-targeted antioxidant SkQ1 is competent in slowing down execution of an aging program responsible for development of age-related senescence.

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Abbreviations

C12TPP:

dodecyltriphenylphosphonium

MitoQ:

10-(6′-ubiquinonyl) decyltriphenylphosphonium

PQ:

decyl plastoquinone

ROS:

reactive oxygen species

SkQs:

cationic derivatives of plastoquinone or methyl plastoquinone

SkQ1:

10-(6′-plastoquinonyl) decyltriphenylphosphonium

SkQR1:

10-(6′-plastoquinonyl) decylrhodamine 19

TPP:

tetraphenylphosphonium

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Correspondence to V. P. Skulachev.

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Published in Russian in Biokhimiya, 2008, Vol. 73, No. 12, pp. 1655–1670.

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Anisimov, V.N., Bakeeva, L.E., Egormin, P.A. et al. Mitochondria-targeted plastoquinone derivatives as tools to interrupt execution of the aging program. 5. SkQ1 prolongs lifespan and prevents development of traits of senescence. Biochemistry Moscow 73, 1329–1342 (2008). https://doi.org/10.1134/S0006297908120055

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