, Volume 73, Issue 2, pp 130-138
Date: 18 Jan 2011

Light damaging action of all-trans-retinal and its derivatives on rhodopsin molecules in the photoreceptor membrane

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We have reproduced the model system containing A2-rhodopsin, NR-PE, A2-PE, and ATR-dimer-PE in order to study photosensitized damage of rhodopsin within photoreceptor membranes of rod outer segments. We have demonstrated that irradiation of such a system with visible light (400–700 nm) distorts the most important functional property of native visual pigment—its ability to regenerate after addition of 11-cis-retinal in the dark. We have also shown that all-trans-retinal bound to membrane phospholipids and rhodopsin has less photosensitizing activity that free all-trans-retinal.

Original Russian Text © M. Yu. Loginova, Ye. V. Rostovtseva, T. B. Feldman, M. A. Ostrovsky, 2008, published in Biokhimiya, 2008, Vol. 73, No. 2, pp. 162–172.
Originally published in Biochemistry (Moscow) On-Line Papers in Press, as Manuscript BM07-249, December 16, 2007.