Biochemistry (Moscow)

, Volume 72, Issue 6, pp 595–607

Biochemical aspects of inflammation

  • V. I. Kulinsky
Review

DOI: 10.1134/S0006297907060028

Cite this article as:
Kulinsky, V.I. Biochemistry Moscow (2007) 72: 595. doi:10.1134/S0006297907060028

Abstract

This review considers biochemical aspects of inflammation. The international literature until December 2006 has been analyzed, with the principal attention paid to the most dynamic problems: enzymology of inflammation, its regulation by hormones and signal transducers, and negative feedbacks, which underlie intensive current studies on pathogenesis, diagnostics, and therapy of inflammation. Such achievements as discoveries of defensins, toll-like receptors, interconnections of inflammation and iron metabolism, the roles of oxidative stress and antioxidant defense, lipoxins, inflammatory components of “non-inflammatory” diseases, and action mechanisms of effective drugs are discussed.

Key words

inflammation enzymes cytokines hormones immune response 

Abbreviations

EGF

epidermal growth factor

FGF

fibroblast growth factor

IL

interleukins

NSAIDs

nonsteroidal antiinflammatory drugs

PAF

platelet-activating factor

PDGF

platelet-derived growth factor

PG

prostaglandins

PK

protein kinases

TF

transcriptional factor

TGF

transforming growth factor

Th

T-helpers

TK

tyrosine kinases

TNF

tumor necrosis factor

VEGF

vascular endothelial growth factor

Copyright information

© Pleiades Publishing, Ltd. 2007

Authors and Affiliations

  • V. I. Kulinsky
    • 1
  1. 1.Department of BiochemistryIrkutsk State Medical UniversityIrkutskRussia

Personalised recommendations