Biochemistry (Moscow)

, Volume 71, Issue 8, pp 851–860

Ubiquitin-protein ligase parkin and its role in the development of Parkinson’s disease

Authors

  • O. A. Buneeva
    • Institute of Biomedical ChemistryRussian Academy of Medical Sciences
    • Institute of Biomedical ChemistryRussian Academy of Medical Sciences
Review

DOI: 10.1134/S0006297906080050

Cite this article as:
Buneeva, O.A. & Medvedev, A.E. Biochemistry (Moscow) (2006) 71: 851. doi:10.1134/S0006297906080050

Abstract

Parkin is a protein encoded by the corresponding parkin gene. It exhibits ubiquitin-protein ligase activity. In this review, we analyze domain structure, substrate specificity, subcellular localization of parkin, and regulation of its activity. Then we discuss data on the effects of various mutations in the parkin gene on structure and functions of this protein and results obtained with parkin knock-out animals. Better understanding of parkin biochemistry, its compartmentalization, functions, and altered functions would help the development of new approaches for the treatment of both inherited and sporadic cases of Parkinson’s disease.

Key words

parkinParkinson’s diseaseproteasomeubiquitinationubiquitin-protein ligasemitochondria

Abbreviations

CDCrel-1

cell division control-related protein

CHIP

C-terminus Hsp 70-interacting protein

EPR

endoplasmic reticulum

Hsp 70

heat shock protein 70 kD

IBR

inbetween RING-site

MAO

monoamine oxidase

Pael-R

parkin-associated endothelial-like receptor

PD

Parkinson’s disease

RING

really interesting gene

UBL-domain

ubiquitin-like domain

UCL-L1

ubiquitin carboxy-terminal hydrolase L1

UPD-domain

unique parkin domain.

Copyright information

© Pleiades Publishing, Inc. 2006