Biochemistry (Moscow)

, Volume 71, Issue 4, pp 448–453

Polymorphism of Δ3,5-Δ2,4-dienoyl-coenzyme A isomerase (the ECH1 gene product protein) in human striated muscle tissue

  • L. I. Kovalyov
  • M. A. Kovalyova
  • P. L. Kovalyov
  • M. V. Serebryakova
  • S. A. Moshkovskii
  • S. S. Shishkin
Article

DOI: 10.1134/S0006297906040146

Cite this article as:
Kovalyov, L.I., Kovalyova, M.A., Kovalyov, P.L. et al. Biochemistry (Moscow) (2006) 71: 448. doi:10.1134/S0006297906040146

Abstract

Two polymorphic variants of the ECH1 gene product protein (Δ3,5-Δ2,4-dienoyl-coenzyme A isomerase) have been revealed by proteomics methods in samples of human striated muscle tissue. These variants are identical in molecular weight (29.7 kD) but different in pI values (6.57 and 6.75) and in amino acid substitution (41 E→A) confirmed by mass spectrometry. The same type of polymorphism has been detected in samples of different tissues of the same person, so these variants are considered (also based on other data) to be allelic. The rates of these alleles in two representative cohorts of Moscow and Minsk residents are similar.

Key words

human muscle proteinsproteomicspolymorphismΔ3,5-Δ2,4-dienoyl-CoA isomerase

Abbreviations

DCAI

Δ3,5-Δ2,4-dienoyl-coenzyme A isomerase

Copyright information

© Pleiades Publishing, Inc. 2006

Authors and Affiliations

  • L. I. Kovalyov
    • 1
  • M. A. Kovalyova
    • 1
  • P. L. Kovalyov
    • 2
  • M. V. Serebryakova
    • 3
  • S. A. Moshkovskii
    • 3
  • S. S. Shishkin
    • 1
  1. 1.Bach Institute of BiochemistryRussian Academy of SciencesMoscowRussia
  2. 2.Tsiolkovsky Moscow University of Aviation TechnologyMoscowRussia
  3. 3.Orekhovich Institute of Biomedical ChemistryRussian Academy of Medical SciencesMoscowRussia