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Migration of a cationic polymer between lipid vesicles

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Abstract

The adsorption of a synthetic polycation, poly(N-ethyl-4-vinylpyridinium bromide) (PEVP), on the surface of bilayer lipid vesicles (liposomes) and the migration of adsorbed macromolecules between the liposomes are studied. Liposomes of three types are used, including (1) traditional two-component liposomes composed of neutral phosphatidylcholine (PC) and anionic cardiolipin (CL); (2) three-component liposomes consisting of PC, CL, and cationic dicetyldimethylammonium bromide (DCMAB); and (3) anionic PC/CL liposomes with a nonionic surfactant, poly(ethylene oxide)-cetyl alcohol ether (Briij 58), incorporated into their bilayers. The adsorption of PEVP on the surface of PC/CL liposomes is accompanied by their aggregation. Using the fluorescence method, it is shown that the units (segments) of the polycation undergo partial redistribution between the liposomes inside the aggregates formed from PC/CL liposomes (with and without a fluorescent label) and PEVP. On the contrary, three-component PC/CL/DCMAB and PC/CL/Briij liposomes are not aggregated, even with the complete neutralization of their charges by adsorbed PEVP. In both cases, the migration of PEVP molecules between individual (nonaggregated) liposomes is observed. Possible reasons for the aggregative stability of the three-component PC/CL/DCMAB and PC/CL/Briij liposomes and the mechanism of interliposome migration of PEVP in such systems are discussed.

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Authors and Affiliations

  1. Department of Chemistry, Moscow State University, Vorob’evy gory, Moscow, 119991, Russia

    D. A. Davydov, E. G. Yaroslavova, A. A. Efimova & A. A. Yaroslavov

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  1. D. A. Davydov
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  2. E. G. Yaroslavova
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  3. A. A. Efimova
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  4. A. A. Yaroslavov
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Original Russian Text © D.A. Davydov, E.G. Yaroslavova, A.A. Efimova, A.A. Yaroslavov, 2009, published in Kolloidnyi Zhurnal, 2009, Vol. 71, No. 1, pp. 56–63.

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Davydov, D.A., Yaroslavova, E.G., Efimova, A.A. et al. Migration of a cationic polymer between lipid vesicles. Colloid J 71, 55–62 (2009). https://doi.org/10.1134/S1061933X09010062

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  • DOI: https://doi.org/10.1134/S1061933X09010062

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