Skip to main content
Log in

IgM and its receptors: Structural and functional aspects

  • Review
  • Published:
Biochemistry (Moscow) Aims and scope Submit manuscript

Abstract

This review combines the data obtained before the beginning of the 1990s with results published during the last two decades. The predominant form of the IgM molecule is a closed ring composed of five 7S subunits and a J chain. The new model of spatial structure of the pentamer postulates nonplanar mushroom-shaped form of the molecule with the plane formed by a radially-directed Fab regions and central protruding portion consisting of Cμ4 domains. Up to the year 2000 the only known Fc-receptor for IgM was pIgR. Interaction of IgM with pIgR results in secretory IgM formation, whose functions are poorly studied. The receptor designated as Fcα/μR is able to bind IgM and IgA. It is expressed on lymphocytes, follicular dendritic cells, and macrophages. A receptor binding IgM only named FcμR has also been described. It is expressed on T- and B-lymphocytes. The discovery of new Fc-receptors for IgM requires revision of notions that interactions between humoral reactions involving IgM and the cells of the immune system are mediated exclusively by complement receptors. In the whole organism, apart from IgM induced by immunization, natural antibodies (NA) are present and comprise in adults a considerable part of the circulating IgM. NA are polyreactive, germ-line-encoded, and emerge during embryogenesis without apparent antigenic stimuli. They demonstrate a broad spectrum of antibacterial activity and serve as first line of defense against microbial and viral infections. NA may be regarded as a transitional molecular form from invariable receptors of innate immunity to highly diverse receptors of adaptive immunity. By means of interaction with autoantigens, NA participate in maintenance of immunological tolerance and in clearance of dying cells. At the same time, NA may act as a pathogenic factor in atherosclerotic lesion formation and in development of tissue damage due to ischemia/reperfusion.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Abbreviations

a.a.:

amino acid residue

C1q:

the 1st component of complement

Fab:

antigen-binding antibody region

Fc:

constant antibody region

Fcα/μR and FcμR:

receptors binding Fc-regions of α- and/or μ-chains

FDC:

follicular dendritic cells

Ig:

immunoglobulins

IgA, IgG, IgE, and IgM:

immunoglobulins of class A, G, E, and M, respectively

NA:

natural antibodies

PC:

phosphorylcholine

pIg:

polymeric immunoglobulins

pIgR:

polymeric immunoglobulin receptor

PTC:

phosphatidylcholine

SC:

secretory component

sIgA and sIgM:

secretory IgA and IgM, correspondingly

References

  1. Flajnik, M. F., Miller, K., and Du Pasquier, L. (2003) in Fundamental Immunology, 5th Edn. (Paul, W. E., ed.) Lippincott-Williams & Wilkins, Philadelphia, pp. 519–570.

    Google Scholar 

  2. Hardy, R. R., and Hayakawa, K. (1994) Adv. Immunol., 55, 297–339.

    PubMed  CAS  Google Scholar 

  3. Henry, C., and Jerne, N. K. (1968) J. Exp. Med., 128, 133–152.

    PubMed  CAS  Google Scholar 

  4. Reth, M. (1992) Annu. Rev. Immunol., 10, 97–121.

    PubMed  CAS  Google Scholar 

  5. Woof, J. M., and Mestecky, J. (2005) Immunol. Rev., 206, 64–82.

    PubMed  CAS  Google Scholar 

  6. Casali, P., and Schettino, E. W. (1996) Curr. Top. Microbiol. Immunol., 210, 167–179.

    PubMed  CAS  Google Scholar 

  7. Baumgarth, N., Herman, O. C., Jager, G. C., Herzenberg, L. A., and Herzenberg, L. A. (1999) Proc. Natl. Acad. Sci. USA, 96, 2250–2255.

    PubMed  CAS  Google Scholar 

  8. Baumgarth, N., Herman, O. C., Jager, G. C., Brown, L. E., Herzenberg, L. A., and Chen, J. (2000) J. Exp. Med., 192, 271–280.

    PubMed  CAS  Google Scholar 

  9. Metzger, H. (1970) Adv. Immunol., 12, 57–116.

    PubMed  CAS  Google Scholar 

  10. Koshland, M. E. (1985) Ann. Rev. Immunol., 3, 425–453.

    CAS  Google Scholar 

  11. Davis, A. C., and Shulman, M. J. (1989) Immunol. Today, 4, 118–128.

    Google Scholar 

  12. Nezlin, R. S. (1998) Immunoglobulins. Structure and Function, Academic Press, N. Y.

    Google Scholar 

  13. Czajkowsky, D. M., and Shao, Z. (2009) Proc. Natl. Acad. Sci. USA, 106, 14960–14965.

    PubMed  CAS  Google Scholar 

  14. Dorrington, K. J., and Mihaesco, C. (1970) Immunochemistry, 7, 651–660.

    PubMed  CAS  Google Scholar 

  15. Beale, D., and Buttress, N. (1969) Biochim. Biophys. Acta, 181, 250–267.

    PubMed  CAS  Google Scholar 

  16. Beale, D., and Feinstein, A. (1970) FEBS Lett., 7, 175–181.

    PubMed  CAS  Google Scholar 

  17. Johansen, F. E., Braathen, R., and Brandtzaeg, P. (2000) Scand. J. Immunol., 52, 240–248.

    PubMed  CAS  Google Scholar 

  18. Koshland, M. E. (1975) Adv. Immunol., 20, 41–69.

    PubMed  CAS  Google Scholar 

  19. Rodgers, J., Early, P., Carter, C., Calame, K., Bond, M., Hood, L., and Wall, R. (1980) Cell, 20, 303–312.

    Google Scholar 

  20. Vassalli, P., Tartakoff, A., Pink, J. R., and Jaton, J. C. (1980) J. Biol. Chem., 255, 11822–11827.

    PubMed  CAS  Google Scholar 

  21. Kurosaki, T. (1999) Annu. Rev. Immunol., 17, 555–592.

    PubMed  CAS  Google Scholar 

  22. Reth, M., and Wienands, J. (1997) Annu. Rev. Immunol., 15, 453–479.

    PubMed  CAS  Google Scholar 

  23. Brezski, R. J., and Monroe, J. G. (2008) Adv. Exp. Med. Biol., 640, 12–21.

    PubMed  CAS  Google Scholar 

  24. Roberts-Thomson, P. J., Jones, D. N., Koh, L. Y., Neoh, S. H., Thomas, M., and Bradley, J. (1984) Austral. N. Z. J. Med., 14, 121–125.

    CAS  Google Scholar 

  25. Pontet, F., and Rousselet, F. (1984) Clin. Chem. Acta, 141, 85–91.

    CAS  Google Scholar 

  26. Klimovich, V. B., and Samoilovich, M. P. (2006) Med. Immunol., 8, 483–500.

    Google Scholar 

  27. Klimovich, V. B., Samoilovich, M. P., and Klimovich, B. V. (2008) Zh. Evolyuts. Biokhim. Fiziol., 44, 131–143.

    CAS  Google Scholar 

  28. Tomasi, T. B., and Bienenstock, J. (1968) Adv. Immunol., 10, 1–96.

    Google Scholar 

  29. Mestecky, J., and Scrohenloher, R. E. (1974) Nature, 249, 650–652.

    PubMed  CAS  Google Scholar 

  30. Chapius, R. M., and Koshland, M. E. (1974) Proc. Natl. Acad. Sci. USA, 71, 657–661.

    CAS  Google Scholar 

  31. Wikler, M., Kohler, H., Shinoda, T., and Putnam, F. W. (1969) Science, 163, 75–78.

    PubMed  CAS  Google Scholar 

  32. Beale, D., and Feinstein, A. (1969) Biochem. J., 112, 187–194.

    PubMed  CAS  Google Scholar 

  33. Mihaesco, C., and Seligman, M. (1968) J. Exp. Med., 127, 431–441.

    PubMed  CAS  Google Scholar 

  34. Mihaesco, C., and Seligman, M. (1968) Immunochemistry, 5, 457–469.

    Google Scholar 

  35. Onoue, K., Kishimoto, T., and Yamamura, Y. (1968) J. Immunol., 100, 238–244.

    PubMed  CAS  Google Scholar 

  36. Plaut, A. G., and Tomasi, T. B. (1970) Proc. Natl. Acad. Sci. USA, 65, 318–322.

    PubMed  CAS  Google Scholar 

  37. Zikan, J., and Bennett, J. C. (1973) Eur. J. Immunol., 3, 415–419.

    PubMed  CAS  Google Scholar 

  38. Jaskey, V. D., and Kepra, D. D. (1987) in Immunology, Vol. 1 (Paul, W., ed.) [Russian translation], Mir, Moscow, pp. 204–254.

    Google Scholar 

  39. Putnam, F. W., Florent, G., Paul, C., Shinoda, T., and Shimizu, F. (1973) Science, 182, 287–291.

    PubMed  CAS  Google Scholar 

  40. Arnold, J. N., Wormald, M. R., Sim, R. B., Rudd, P. M., and Dwek, R. A. (2007) Annu. Rev. Immunol., 25, 21–50.

    PubMed  CAS  Google Scholar 

  41. Arnold, J. N., Wormald, M. R., Suter, D. M., Radcliffe, C. M., Harvey, D. J., Dwek, R. A., Rudd, P. M., and Sim, R. B. (2005) J. Biol. Chem., 280, 29080–29087.

    PubMed  CAS  Google Scholar 

  42. Volkov, V. V., Lapuk, V. A., Kayushina, R. L., Shtykova, E. V., Varlamova, E. Yu., Malfois, M., and Svergun, D. I. (2003) J. Appl. Cryst., 36, 503–508.

    CAS  Google Scholar 

  43. Brewer, J. W., Randall, T. D., Parkhouse, R. M. E., and Corley, R. B. (1994) Immunol. Today, 15, 165–168.

    PubMed  CAS  Google Scholar 

  44. Wiersma, E. J., Collins, C., Fazel, S., and Shulman, M. J. (1998) J. Immunol., 160, 5979–5989.

    PubMed  CAS  Google Scholar 

  45. Fazel, S., Wiersma, E. J., and Shulman, M. J. (1997) Int. Immunol., 9, 1149–1158.

    PubMed  CAS  Google Scholar 

  46. Sorensen, V., Rasmussen, I. B., Sundvold, V., Michaelsen, T. E., and Sandlie, I. (2000) Int. Immunol., 12, 19–27.

    PubMed  CAS  Google Scholar 

  47. Brandtzaeg, P. (1975) Immunology, 29, 559–570.

    PubMed  CAS  Google Scholar 

  48. Lindh, E., and Bjork, I. (1976) Eur. J. Biochem., 62, 271–278.

    PubMed  CAS  Google Scholar 

  49. Prinsloo, E., Oosthuizen, V., van de Venter, M., and Naude, R. J. (2009) Immunol. Lett., 122, 94–98.

    PubMed  CAS  Google Scholar 

  50. Daeron, M. (1997) Annu. Rev. Immunol., 15, 203–234.

    PubMed  CAS  Google Scholar 

  51. Ravetch, J. V., and Bolland, S. (2001) Annu. Rev. Immunol., 19, 275–290.

    PubMed  CAS  Google Scholar 

  52. Nimmerjahn, F., and Ravetch, J. V. (2007) Adv. Immunol., 96, 179–204.

    PubMed  CAS  Google Scholar 

  53. Mostov, K. E., and Blobel, G. (1982) J. Biol. Chem., 257, 11816–11821.

    PubMed  CAS  Google Scholar 

  54. Krajci, P., Solberg, R., Sandberg, M., Oyen, O., Jahnsen, T., and Brandtzaeg, P. (1989) Biochem. Biophys. Res. Commun., 158, 783–789.

    PubMed  CAS  Google Scholar 

  55. Kaetzel, C. S. (2005) Immunol. Rev., 206, 83–99.

    PubMed  CAS  Google Scholar 

  56. Pumphrey, R. S. H. (1986) Immunol. Today, 7, 206–210.

    CAS  Google Scholar 

  57. Hughes, G. J., Frutiger, S., Savoy, L. A., Reason, A. J., Morris, H. R., and Jaton, J. C. (1997) FEBS Lett., 410, 443–446.

    PubMed  CAS  Google Scholar 

  58. Sletten, K., Christensen, T. B., and Brandtzaeg, P. (1975) Immunochemistry, 12, 783–785.

    PubMed  CAS  Google Scholar 

  59. Bakos, M. A., Kurosky, A., and Goldblum, R. M. (1991) J. Immunol., 147, 3419–3426.

    PubMed  CAS  Google Scholar 

  60. Mostov, K. E. (1994) Annu. Rev. Immunol., 12, 63–84.

    PubMed  CAS  Google Scholar 

  61. Okamoto, C. T., Shia, S. P., Bird, C., Mostov, K. E., and Roth, M. G. (1992) J. Biol. Chem., 267, 9925–9932.

    PubMed  CAS  Google Scholar 

  62. Hunziker, W., Whitney, J. A., and Mellman, I. (1991) Cell, 67, 617–627.

    PubMed  CAS  Google Scholar 

  63. Casanova, J. E., Breitfeld, P. P., Ross, S. A., and Mostov, K. E. (1990) Science, 248, 742–745.

    PubMed  CAS  Google Scholar 

  64. Norderhaug, I. N., Johansen, F. E., Schjerven, H., and Brandtzaeg, P. (1999) Crit. Rev. Immunol., 19, 481–508.

    PubMed  CAS  Google Scholar 

  65. Almogren, A., Bonner, A., Perkins, S. J., and Kerr, M. A. (2009) Mol. Immunol., 46, 1534–1541.

    PubMed  CAS  Google Scholar 

  66. Apodaca, G., Katz, L. A., and Mostov, K. E. (1994) J. Cell Biol., 125, 67–86.

    PubMed  CAS  Google Scholar 

  67. Ferkol, T., Kaetzel, C. S., and Davis, P. B. (1993) J. Clin. Invest., 92, 2394–2400.

    PubMed  CAS  Google Scholar 

  68. Ferkol, T., Perales, J. C., Eckman, E., Kaetzel, C. S., Hanson, R. W., and Davis, P. B. (1995) J. Clin. Invest., 95, 493–502.

    PubMed  CAS  Google Scholar 

  69. Kaetzel, C. S., and Mostov, K. (2005) in Mucosal Immunology, 3rd Edn., Vol. 1 (Mestecky, J., Bienenstock, J., Lamm, M., Strober, W., McGhee, J., and Mayer, L., eds.) Academic Press, San-Diego, pp. 211–250.

    Google Scholar 

  70. Coyne, R. S., Siebrecht, M., Peitsch, M. C., and Casanova, J. E. (1994) J. Biol. Chem., 269, 31620–31625.

    PubMed  CAS  Google Scholar 

  71. Roe, M., Norderhaug, I. N., Brandtzaeg, P., and Johansen, F. E. (1999) J. Immunol., 162, 6046–6052.

    PubMed  CAS  Google Scholar 

  72. Brandtzaeg, P., and Johansen, F. E. (2001) Trends Immunol., 22, 545–546.

    PubMed  CAS  Google Scholar 

  73. Hamburger, A. E., West, A. P., Jr., and Bjorkman, P. J. (2004) Structure, 12, 1925–1935.

    PubMed  CAS  Google Scholar 

  74. Mathur, A., Lynch, R. G., and Kohler, G. (1988) J. Immunol., 141, 1855–1862.

    PubMed  CAS  Google Scholar 

  75. Ohno, T., Kubagawa, H., Sanders, S. K., and Cooper, M. D. (1990) J. Exp. Med., 172, 1165–1175.

    PubMed  CAS  Google Scholar 

  76. Shibuya, A., and Honda, S. (2006) Springer Semin. Immunopathol., 28, 377–382.

    PubMed  CAS  Google Scholar 

  77. Shibuya, A., Sakamoto, N., Shimizu, Y., Shibuya, K., Osawa, M., Hiroyama, T., Eyre, H. J., Sutherland, G. R., Endo, Y., Fujita, T., Miyabayashi, T., Sakano, S., Tsuji, T., Nakayama, E., Phillips, J. H., Lanier, L. L., and Nakauchi, H. (2000) Nat. Immunol., 1, 441–446.

    PubMed  CAS  Google Scholar 

  78. Shimizu, Y., Honda, S., Yotsumoto, K., Tahara-Hanaoka, S., Eyre, H. J., Sutherland, G. R., Endo, Y., Shibuya, K., Koyama, A., Nakauchi, H., and Shibuya, A. (2001) Immunogenetics, 53, 709–711.

    PubMed  CAS  Google Scholar 

  79. Sakamoto, N., Shibuya, K., Shimiz, Y., Yotsumoto, K., Miyabavashi, T., Sakano, S., Tsuji, T., Nakavama, E., Nakauchi, H., and Shibuya, A. (2001) Eur. J. Immunol., 31, 1310–1316.

    PubMed  CAS  Google Scholar 

  80. Yang, L., Shen, L., Shao, Y., Zhao, Q., and Zhang, W. (2009) Cell Immunol., 258, 78–82.

    PubMed  CAS  Google Scholar 

  81. Cho, Y., Usui, K., Honda, S., Tahara-Hanaoka, S., Shibuya, K., and Shibuya, A. (2006) Biochem. Biophys. Res. Commun., 345, 474–478.

    PubMed  CAS  Google Scholar 

  82. Kikuno, K., Kang, D. W., Tahara, K., Torii, I., Kubagawa, H. M., Ho, K. J., Baudino, L., Nishizaki, N., Shibuya, A., and Kubagawa, H. (2007) Eur. J. Immunol., 37, 3540–3550.

    PubMed  CAS  Google Scholar 

  83. Wang, R., Fu, Y., Zhao, Q., Pan, L., and Zhang, W. (2009) Biochem. Biophys. Res. Commun., 381, 148–152.

    PubMed  CAS  Google Scholar 

  84. Otten, M. A., and van Egmond, M. (2004) Immunol. Lett., 92, 23–31.

    PubMed  CAS  Google Scholar 

  85. Pleass, R. J., Areschoug, T., Lindahl, G., and Woof, J. M. (2001) J. Biol. Chem., 276, 8197–8204.

    PubMed  CAS  Google Scholar 

  86. Ghumra, A., Shi, J., Mcintosh, R. S., Rasmussen, I. B., Braathen, R., Johansen, F. E., Sandlie, I., Mongini, P. K., Areschoug, T., Lindahl, G., Lewis, M. J., Woof, J. M., and Pleass, R. J. (2009) Eur. J. Immunol., 39, 1147–1156.

    PubMed  CAS  Google Scholar 

  87. McDonald, K. J., Cameron, A. J., Allen, J. M., and Jardine, A. G. (2002) Biochem. Biophys. Res. Commun., 290, 438–442.

    PubMed  CAS  Google Scholar 

  88. Kurita, N., Honda, S., Usui, K., Shimizu, Y., Miyamoto, A., Tahara-Hanaoka, S., Shibuya, K., and Shibuya, A. (2009) Mol. Immunol., 46, 749–753.

    PubMed  CAS  Google Scholar 

  89. Kubagawa, H., Oka, S., Kubagawa, Y., Torii, I., Takayama, E., Kang, D. W., Gartland, G. L., Bertoli, L. F., Mori, H., Takatsu, H., Kitamura, T., Ohno, H., and Wang, J. Y. (2009) J. Exp. Med., 206, 2779–2793.

    PubMed  CAS  Google Scholar 

  90. Nezlin, R., and Ghetie, V. (2004) Adv. Immunol., 82, 155–215.

    PubMed  CAS  Google Scholar 

  91. Kazeeva, T. N., and Shevelev, A. B. (2009) Biochemistry (Moscow), 74, 12–21.

    CAS  Google Scholar 

  92. Pleass, R. J., and Woof, J. M. (2001) Trends Parasitol., 17, 545–551.

    PubMed  CAS  Google Scholar 

  93. Woof, J. M. (2002) Biochem. Soc. Trans., 30, 491–494.

    PubMed  CAS  Google Scholar 

  94. Vercammen, M., Scorza, T., El Bouhdidi, A., van Beeck, K., Carlier, Y., Dubremetz, J. F., and Verschueren, H. (1999) Parasite Immunol., 21, 555–563.

    PubMed  CAS  Google Scholar 

  95. Vincendeau, P., and Daeron, M. (1989) J. Immunol., 142, 1702–1709.

    PubMed  CAS  Google Scholar 

  96. Ghumra, A., Semblat, J. P., McIntosh, R. S., Raza, A., Rasmussen, I. B., Braathen, R., Johansen, F. E., Sandlie, I., Mongini, P. K., Rowe, J. A., and Pleass, R. J. (2008) J. Immunol., 181, 1988–2000.

    PubMed  CAS  Google Scholar 

  97. LeBien, T. W. (2000) Blood, 96, 9–23.

    PubMed  CAS  Google Scholar 

  98. Hayakawa, K., and Hardy, R. R. (2000) Curr. Opin. Immunol., 12, 346–353.

    PubMed  CAS  Google Scholar 

  99. Montecino-Rodriguez, E., Leathers, H., and Dorshkind, K. (2006) Nat. Immunol., 7, 293–301.

    PubMed  CAS  Google Scholar 

  100. Zhou, Z. H., and Notkins, A. L. (2004) Clin. Exp. Immunol., 137, 88–100.

    PubMed  CAS  Google Scholar 

  101. Kantor, A. B., and Herzenberg, L. A. (1993) Annu. Rev. Immunol., 11, 501–538.

    PubMed  CAS  Google Scholar 

  102. Martin, F., and Kearney, J. F. (2001) Curr. Opin. Immunol., 13, 195–201.

    PubMed  CAS  Google Scholar 

  103. Haas, K. M., Poe, J. C., Steeber, D. A., and Tedder, T. F. (2005) Immunity, 23, 7–18.

    PubMed  CAS  Google Scholar 

  104. Alugupalli, K. R., Leong, J. M., Woodland, R. T., Muramatsu, M., Honjo, T., and Gerstein, R. M. (2004) Immunity, 21, 379–390.

    PubMed  CAS  Google Scholar 

  105. Feeney, A. J. (1990) J. Exp. Med., 172, 1377–1390.

    PubMed  CAS  Google Scholar 

  106. Casali, P., and Schettino, E. W. (1996) Curr. Top. Microbiol. Immunol., 210, 167–179.

    PubMed  CAS  Google Scholar 

  107. Baba, Y., Pelayo, R., and Kincade, P. W. (2004) Trends Immunol., 25, 645–649.

    PubMed  CAS  Google Scholar 

  108. Pillai, S., Cariappa, A., and Moran, S. T. (2005) Annu. Rev. Immunol., 23, 161–196.

    PubMed  CAS  Google Scholar 

  109. McHeyzer-Williams, L. J., and McHeyzer-Williams, M. G. (2005) Annu. Rev. Immunol., 23, 487–513.

    PubMed  CAS  Google Scholar 

  110. Hardy, R. R. (2006) Curr. Opin. Immunol., 18, 547–555.

    PubMed  CAS  Google Scholar 

  111. Roy, B., Shukla, S., Lyszkiewicz, M., Krey, M., Viegas, N., Duber, S., and Weiss, S. (2009) Mol. Immunol., 46, 1613–1619.

    PubMed  CAS  Google Scholar 

  112. Cole, L. E., Yang, Y., Elkins, K. L., Fernandez, E. T., Qureshi, N., Shlomchik, M. J., Herzenberg, L. A., Herzenberg, L. A., and Vogel, S. N. (2009) Proc. Natl. Acad. Sci. USA, 106, 4343–4348.

    PubMed  CAS  Google Scholar 

  113. Dogan, I., Bertocci, B., Vilmont, V., Delbos, F., Megret, J., Storck, S., Reynaud, C. A., and Weill, J. C. (2009) Nat. Immunol., 10, 292–299.

    Google Scholar 

  114. Murakami, M., and Honjo, T. (1995) Immunol. Today, 16, 534–539.

    PubMed  CAS  Google Scholar 

  115. Edberg, S. C., Bronson, P. M., and van Oss, C. J. (1972) Immunochemistry, 9, 273–288.

    PubMed  CAS  Google Scholar 

  116. Crothers, D. M., and Metzger, H. (1972) Immunochemistry, 9, 341–357.

    PubMed  CAS  Google Scholar 

  117. Bendtzen, K., Hansen, M. B., Ross, C., and Svenson, M. (1998) Immunol. Today, 19, 209–211.

    PubMed  CAS  Google Scholar 

  118. Notkins, A. L. (2004) Trends Immunol., 25, 174–179.

    PubMed  CAS  Google Scholar 

  119. Haury, M., Sundblad, A., Grandien, A., Barreau, C., Coutinho, A., and Nobrega, A. (1997) Eur. J. Immunol., 27, 1557–1563.

    PubMed  CAS  Google Scholar 

  120. Mouthon, L., Nobrega, A., Nicolas, N., Kaveri, S. V., Barreau, C., Coutinho, A., and Kazatchkine, M. D. (1995) Proc. Natl. Acad. Sci. USA, 92, 3839–3843.

    PubMed  CAS  Google Scholar 

  121. Manivel, V., Sahoo, N. C., Salunke, D. M., and Rao, K. V. (2000) Immunity, 13, 611–620.

    PubMed  CAS  Google Scholar 

  122. Wedemayer, G. J., Patten, P. A., Wang, L. H., Schultz, P. G., and Stevens, R. C. (1997) Science, 276, 1665–1669.

    PubMed  CAS  Google Scholar 

  123. Yin, J., Beuscher, A. Et., Andryski, S. E., Stevens, R. C., and Schultz, P. G. (2003) J. Mol. Biol., 330, 651–656.

    PubMed  CAS  Google Scholar 

  124. Satoh, J., Prabhakar, B. S., Haspel, M. V., Ginsberg-Fellner, F., and Notkins, A. L. (1983) N. Engl. J. Med., 309, 217–220.

    PubMed  CAS  Google Scholar 

  125. Prabhakar, B. S., Saegusa, J., Onodera, T., and Notkins, A. L. (1984) J. Immunol., 133, 2815–2817.

    PubMed  CAS  Google Scholar 

  126. Dighiero, G., Lymberi, P., Mazie, J. C., Rouyre, S., Butler-Browne, G. S., Whalen, R. G., and Avrameas, S. (1983) J. Immunol., 131, 2267–2272.

    PubMed  CAS  Google Scholar 

  127. Avrameas, S. (1991) Immunol. Today, 12, 154–159.

    PubMed  CAS  Google Scholar 

  128. Coutinho, A., Kazatchkine, M. D., and Avrameas, S. (1995) Curr. Opin. Immunol., 7, 812–818.

    PubMed  CAS  Google Scholar 

  129. Mond, J. J., Vos, Q., Lees, A., and Snapper, C. M. (1995) Curr. Opin. Immunol., 7, 349–354.

    PubMed  CAS  Google Scholar 

  130. Martin, F., Oliver, A. M., and Kearney, J. F. (2001) Immunity, 14, 617–629.

    PubMed  CAS  Google Scholar 

  131. Baumgarth, N., Tung, J. W., and Herzenberg, L. A. (2005) Springer Semin. Immunopathol., 26, 347–362.

    PubMed  CAS  Google Scholar 

  132. Vos, Q., Lees, A., Wu, Z. Q., Snapper, C. M., and Mond, J. J. (2000) Immunol. Rev., 176, 154–170.

    PubMed  CAS  Google Scholar 

  133. Fehr, T., Naim, H. Y., Bachmann, M. F., Ochsenbein, A. F., Spielhofer, P., Bucher, E., Hengartner, H., Billeter, M. A., and Zinkernagel, R. M. (1998) Nat. Med., 4, 945–948.

    PubMed  CAS  Google Scholar 

  134. Zhou, Z. H., Tzioufas, A. G., and Notkins, A. L. (2007) J. Autoimmun., 29, 219–228.

    PubMed  CAS  Google Scholar 

  135. Nielsen, C. H., Fischer, E. M., and Leslie, R. G. (2000) Immunology, 100, 4–12.

    PubMed  CAS  Google Scholar 

  136. Feinstein, A., Richardson, N., and Taussig, M. I. (1986) Immunol. Today, 7, 169–174.

    CAS  Google Scholar 

  137. Arya, S., Chen, F., Spycher, S., Isenman, D. E., Shulman, M. J., and Painter, R. H. (1994) J. Immunol., 152, 1206–1212.

    PubMed  CAS  Google Scholar 

  138. Miletic, V. D., and Frank, M. M. (1995) Curr. Opin. Immunol., 7, 41–47.

    PubMed  CAS  Google Scholar 

  139. Wright, J. F., Shulman, M. J., Isenman, D. E., and Painter, R. H. (1990) Biol. Chem., 265, 10506–10513.

    CAS  Google Scholar 

  140. Poon, P. H., Morrison, S. L., and Schumaker, V. N. (1995) J. Biol. Chem., 270, 8571–8577.

    PubMed  CAS  Google Scholar 

  141. Kishore, U., Gupta, S. K., Perdikoulis, M. V., Kojouharova, M. S., Urban, B. C., and Reid, K. B. (2003) J. Immunol., 171, 812–820.

    PubMed  CAS  Google Scholar 

  142. Poon, P. H., Phillips, M. L., and Schumaker, V. N. (1985) J. Biol. Chem., 260, 9357–9365.

    PubMed  CAS  Google Scholar 

  143. Borsos, T., and Rapp, H. J. (1965) Science, 150, 505–506.

    PubMed  CAS  Google Scholar 

  144. Cooper, N. R., Nemerow, G. R., and Mayes, J. T. (1983) Springer Semin. Immunopathol., 6, 195–212.

    PubMed  CAS  Google Scholar 

  145. Hughey, C. T., Brewer, J. W., Colosia, A. D., Rosse, W. F., and Corley, R. B. (1998) J. Immunol., 161, 4091–4097.

    PubMed  CAS  Google Scholar 

  146. Morgan, B. P., Marchbank, K. J., Longhi, M. P., Harris, C. L., and Gallimore, A. M. (2005) Immunol. Lett., 97, 171–179.

    PubMed  CAS  Google Scholar 

  147. Tack, B. F., Harrison, R. A., Janatova, J., Thomas, M. L., and Prahl, J. W. (1980) Proc. Natl. Acad. Sci. USA, 77, 5764–5768.

    PubMed  CAS  Google Scholar 

  148. Carroll, M. C. (2008) Vaccine, 26,Suppl. 8, 128–133.

    Google Scholar 

  149. Petty, H. R., Worth, R. G., and Todd, R. R. (2002) Immunol. Res., 25, 75–95.

    PubMed  CAS  Google Scholar 

  150. Erdei, A., Isaak, A., Torok, K., Sandor, N., Kremlitzka, M., Prechl, J., and Bajtay, Z. (2009) Mol. Immunol., 46, 2767–2773.

    PubMed  CAS  Google Scholar 

  151. Ferguson, A. R., Youd, M. E., and Corley, R. B. (2004) Int. Immunol., 16, 1411–1422.

    PubMed  CAS  Google Scholar 

  152. Heyman, B. (2000) Annu. Rev. Immunol., 18, 709–737.

    PubMed  CAS  Google Scholar 

  153. Bruggemann, M., and Rajewsky, K. (1982) Cell. Immunol., 71, 365–373.

    PubMed  CAS  Google Scholar 

  154. Harte, P. G., Cooke, A., and Playfair, J. H. L. (1983) Nature, 302, 256–258.

    PubMed  CAS  Google Scholar 

  155. Heyman, B., Pilstrom, L., and Shulman, M. J. (1988) J. Exp. Med., 167, 1999–2004.

    PubMed  CAS  Google Scholar 

  156. Heyman, B., and Wigzell, H. (1985) Scand. J. Immunol., 21, 255–266.

    PubMed  CAS  Google Scholar 

  157. Corley, R. B., Morehouse, E. M., and Ferguson, A. R. (2005) Scand. J. Immunol., 62, 55–61.

    PubMed  CAS  Google Scholar 

  158. Applequist, S. E., Dahlstrom, J., Jiang, N., Molina, H., and Heyman, B. (2000) J. Immunol., 165, 2398–2403.

    PubMed  CAS  Google Scholar 

  159. Carlsson, F., Getahun, A., Rutemark, C., and Heyman, B. (2009) Scand. J. Immunol., 70, 77–84.

    PubMed  CAS  Google Scholar 

  160. Taylor, B., Wright, J. F., Arya, S., Isenman, D. E., Shulman, M., and Painter, J. R. H. (1994) J. Immunol., 153, 5303–5313.

    PubMed  CAS  Google Scholar 

  161. Youd, M. E., Ferguson, A. R., and Corley, R. B. (2002) Eur. J. Immunol., 32, 2328–2337.

    PubMed  CAS  Google Scholar 

  162. Fearon, D. T. (1993) Curr. Opin. Immunol., 5, 341–348.

    PubMed  CAS  Google Scholar 

  163. Fearon, D. T., and Carroll, M. C. (2000) Annu. Rev. Immunol., 18, 393–422.

    PubMed  CAS  Google Scholar 

  164. Qin, D., Wu, J., Carroll, M. C., Burton, G. F., Szakal, A., and Tew, J. G. (1998) J. Immunol., 161, 4549–4554.

    PubMed  CAS  Google Scholar 

  165. Chen, Z., Koralov, S. B., Gendelman, M., Carroll, M. C., and Kelsoe, G. (2000) J. Immunol., 164, 4522–4532.

    PubMed  CAS  Google Scholar 

  166. Bergmann-Leitner, E. S., Leitner, W. W., and Tsokos, G. C. (2006) Clin. Immunol., 121, 177–185.

    PubMed  CAS  Google Scholar 

  167. Getahun, A., and Heyman, B. (2006) Immunol. Lett., 104, 38–45.

    PubMed  CAS  Google Scholar 

  168. Honda, S., Kurita, N., Miyamoto, A., Cho, Y., Usui, K., Takeshita, K., Takahashi, S., Yasui, T., Kikutani, H., Kinoshita, T., Fujita, T., Tahara-Hanaoka, S., Shibuya, K., and Shibuya, A. (2009) Proc. Natl. Acad. Sci. USA, 106, 11230–11235.

    PubMed  CAS  Google Scholar 

  169. Ochsenbein, A. F., Fehr, T., Lutz, C., Suter, M., Brombacher, F., Hengartner, H., and Zinkernagel, R. M. (1999) Science, 286, 2156–2159.

    PubMed  CAS  Google Scholar 

  170. Ehrenstein, M. R., O’Keefe, T. L., Davies, S. L., and Neuberger, M. S. (1998) Proc. Natl. Acad. Sci. USA, 95, 10089–10093.

    PubMed  CAS  Google Scholar 

  171. Boes, M., Esau, C., Fischer, M. B., Schmidt, T., Carroll, M., and Chen, J. (1998) J. Immunol., 160, 4776–4787.

    PubMed  CAS  Google Scholar 

  172. Boes, M., Prodeus, A. P., Schmidt, T., Carroll, M. C., and Chen, J. (1998) J. Exp. Med., 188, 2381–2386.

    PubMed  CAS  Google Scholar 

  173. Baumgarth, N., Herman, O. C., Jager, G. C., Brown, L. E., Herzenberg, L. A., and Chen, J. (2000) J. Exp. Med., 192, 271–280.

    PubMed  CAS  Google Scholar 

  174. Zhou, Z. H., Zhang, Y., Hu, Y. F., Wahl, L. M., Cisar, J. O., and Notkins, A. L. (2007) Cell Host Microbe, 1, 51–61.

    PubMed  CAS  Google Scholar 

  175. Racine, R., and Winslow, G. M. (2009) Immunol. Lett., 125, 79–85.

    PubMed  CAS  Google Scholar 

  176. Davies, A. J. S. (2008) Autoimmun. Rev., 7, 538–543.

    PubMed  CAS  Google Scholar 

  177. Backhed, F., Ley, R. E., Sonnenburg, J. L., Peterson, D. A., and Gordon, J. I. (2005) Science, 307, 1915–1920.

    PubMed  Google Scholar 

  178. Macpherson, A. J., and Harris, N. L. (2004) Nat. Rev. Immunol., 4, 478–485.

    PubMed  CAS  Google Scholar 

  179. Peterson, D. A., McNulty, N. P., Guruge, J. L., and Gordon, J. I. (2007) Cell Host Microbe, 2, 328–339.

    PubMed  CAS  Google Scholar 

  180. Woof, J. M., and Kerr, M. A. (2006) J. Pathol., 208, 270–282.

    PubMed  CAS  Google Scholar 

  181. Rojas, R., and Apodaca, G. (2002) Nat. Rev. Mol. Cell Biol., 3, 944–955.

    PubMed  CAS  Google Scholar 

  182. Yel, L. (2010) J. Clin. Immunol., 30, 10–16.

    PubMed  CAS  Google Scholar 

  183. Lutz, H. U., and Miescher, S. (2008) Autoimmun. Rev., 7, 405–409.

    PubMed  CAS  Google Scholar 

  184. Ehrenstein, M. R., Cook, H. T., and Neuberger, M. S. (2000) J. Exp. Med., 191, 1253–1258.

    PubMed  CAS  Google Scholar 

  185. Boes, M., Schmidt, T., Linkemann, K., Beaudette, B. C., Marshak-Rothstein, A., and Chen, J. (2000) Proc. Natl. Acad. Sci. USA, 97, 1184–1189.

    PubMed  CAS  Google Scholar 

  186. Boes, M. (2000) Mol. Immunol., 37, 1141–1149.

    PubMed  CAS  Google Scholar 

  187. Manson, J. J., Mauri, C., and Ehrenstein, M. R. (2005) Springer Semin. Immunopathol., 26, 425–432.

    PubMed  CAS  Google Scholar 

  188. Kroese, F. G., de Waard, R., and Bos, N. A. (1996) Semin. Immunol., 8, 11–18.

    PubMed  CAS  Google Scholar 

  189. Claflin, J. L., Rudikoff, S., Potter, M., and Davie, J. M. (1975) J. Exp. Med., 141, 608–619.

    PubMed  CAS  Google Scholar 

  190. Potter, M. (2007) Adv. Cancer Res., 98, 17–51.

    PubMed  CAS  Google Scholar 

  191. Diamond, B., and Scharff, M. D. (1984) Proc. Natl. Acad. Sci. USA, 81, 5841–5844.

    PubMed  CAS  Google Scholar 

  192. Diamond, B., Katz, J. B., Paul, E., Aranow, C., Lustgarten, D., and Scharff, M. D. (1992) Annu. Rev. Immunol., 10, 731–757.

    PubMed  CAS  Google Scholar 

  193. Mercolino, T. J., Arnold, L. W., Hawkins, L. A., and Haughton, G. (1988) J. Exp. Med., 168, 687–698.

    PubMed  CAS  Google Scholar 

  194. Peng, Y. F., Martin, D. A., Kenkel, J., Zhang, K., Ogden, C. A., and Elkon, K. B. (2007) J. Autoimmun., 29, 303–309.

    PubMed  CAS  Google Scholar 

  195. Lutz, H. U., Binder, C. J., and Kaveri, S. (2009) Trends Immunol., 30, 43–51.

    PubMed  CAS  Google Scholar 

  196. Peng, Y., Kowalewski, R., Kimb, S., and Elkon, K. B. (2005) Mol. Immunol., 42, 781–787.

    PubMed  CAS  Google Scholar 

  197. Fu, M., Fan, P. S., Li, W., Li, C. X., Xing, Y., An, J. G., Wang, G., Fan, X. L., Gao, T. W., Liu, Y. F., and Ikeda, S. (2007) Apoptosis, 12, 355–362.

    PubMed  CAS  Google Scholar 

  198. Lutz, H. U. (2007) J. Autoimmun., 29, 287–294.

    PubMed  CAS  Google Scholar 

  199. Binder, C. J. (2010) J. Clin. Immunol., 30, 56–60.

    Google Scholar 

  200. Binder, C. J., Shaw, P. X., Chang, M. K., Boullier, A., Hartvigsen, K., Horkko, S., Miller, Y. I., Woelkers, D. A., Corr, M., and Witztum, J. L. (2005) J. Lipid Res., 46, 1353–1363.

    PubMed  CAS  Google Scholar 

  201. Tsimikas, S., Brilakis, E. S., Lennon, R. J., Miller, E. R., Witztum, J. L., McConnell, J. P., Kornman, K. S., and Berger, P. B. (2007) J. Lipid Res., 48, 425–433.

    PubMed  CAS  Google Scholar 

  202. Su, J., Georgiades, A., Wu, R., Thulin, T., de Faire, U., and Frostegard, J. (2006) Atherosclerosis, 188, 160–166.

    PubMed  CAS  Google Scholar 

  203. Lutz, J., Turmel, K., and Heemann, U. (2010) J. Inflamm., 7, 27–35.

    Google Scholar 

  204. Weiser, M. R., Williams, J. P., Moore, F. D., Jr., Kobzik, L., Ma, M., Hechtman, H. B., and Carroll, M. C. (1996) J. Exp. Med., 183, 2343–2348.

    PubMed  CAS  Google Scholar 

  205. Williams, J. P., Pechet, T. T., Weiser, M. R., Reid, R., Kobzik, L., Moore, F. D., Jr., Carroll, M. C., and Hechtman, H. B. (1999) J. Appl. Physiol., 86, 938–942.

    PubMed  CAS  Google Scholar 

  206. Zhang, M., Austen, W. G., Jr., Chiu, I., Alicot, E. M., Hung, R., Ma, M., Verna, N., Xu, M., Hechtman, H. B., Moore, F. D., Jr., and Carroll, M. C. (2004) Proc. Natl. Acad. Sci. USA, 101, 3886–3891.

    PubMed  CAS  Google Scholar 

  207. Zhang, M., Alicot, E. M., and Carroll, M. C. (2008) Mol. Immunol., 45, 4036–4039.

    PubMed  CAS  Google Scholar 

  208. Diepenhorst, G. M., van Gulik, T. M., and Hack, C. E. (2009) Ann. Surg., 249, 889–899.

    PubMed  Google Scholar 

  209. Fuster, M. M., and Esko, J. D. (2005) Nat. Rev. Cancer, 5, 526–542.

    PubMed  CAS  Google Scholar 

  210. Karsten, U., Diotel, C., Klich, G., Paulsen, H., Goletz, S., Muller, S., and Hanisch, F. G. (1998) Cancer Res., 58, 2541–2549.

    PubMed  CAS  Google Scholar 

  211. Brandlein, S., Pohle, T., Ruoff, N., Wozniak, E., Muller-Hermelink, H. K., and Vollmers, H. P. (2003) Cancer Res., 63, 7995–8005.

    PubMed  Google Scholar 

  212. Brandlein, S., Lorenz, J., Ruoff, N., Hensel, F., Beyer, I., Muller, J., Neukam, K., Illert, B., Eck, M., Muller-Hermelink, H. K., and Vollmers, H. P. (2002) Hum. Antibod., 4, 107–119.

    Google Scholar 

  213. Vollmers, H. P., and Brandlein, S. (2009) New Biotechnol., 5, 294–298.

    Google Scholar 

  214. Schwartz-Albiez, R., Laban, S., Eichmuller, S., and Kirschfink, M. (2008) Autoimmun. Rev., 7, 491–495.

    PubMed  CAS  Google Scholar 

  215. Klimovich, V. B. (2002) Zh. Evolyuts. Biokhim. Fiziol., 38, 562–574.

    CAS  Google Scholar 

  216. Marchalonis, J. J., Kaveri, S., Lacroix-Desmazes, S., and Kazatchkine, M. D. (2002) FASEB J., 16, 842–848.

    PubMed  CAS  Google Scholar 

  217. Nobrega, A., Grandien, A., Haury, M., Hecker, L., Malanchere, E., and Coutinho, A. (1998) Eur. J. Immunol., 28, 1204–1215.

    PubMed  CAS  Google Scholar 

  218. Janeway, C. A., Jr., and Medzhitov, R. (2002) Annu. Rev. Immunol., 20, 197–216.

    PubMed  CAS  Google Scholar 

  219. Volanakis, J. E. (2001) Mol. Immunol., 38, 189–197.

    PubMed  CAS  Google Scholar 

  220. De Lalla, C., Fagioli, C., Cessi, F. S., Smilovich, D., and Sitia, R. (1998) Mol. Immunol., 35, 837–845.

    PubMed  Google Scholar 

  221. Johansen, F. E., Braathen, R., and Brandtzaeg, P. (2000) Scand. J. Immunol., 52, 240–248.

    PubMed  CAS  Google Scholar 

  222. Samoilovich, M. P., Gryazeva, I. V., Klimovich, B. V., Artem’eva, A. K., Pisareva, M. N., and Klimovich, V. B. (2008) Ros. Immunol. Zh., 2, 398–404.

    Google Scholar 

  223. Brandtzaeg, P. (2007) Vaccine, 25, 5467–5484.

    PubMed  CAS  Google Scholar 

  224. Braathen, R., Hohman, V. S., Brandtzaeg, P., and Johansen, F. E. (2007) J. Immunol., 178, 1589–1597.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to V. B. Klimovich.

Additional information

Original Russian Text © V. B. Klimovich, 2011, published in Biokhimiya, 2011, Vol. 76, No. 5, pp. 654–672.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Klimovich, V.B. IgM and its receptors: Structural and functional aspects. Biochemistry Moscow 76, 534–549 (2011). https://doi.org/10.1134/S0006297911050038

Download citation

  • Received:

  • Revised:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S0006297911050038

Key words

Navigation