Abstract
Parkin is a protein encoded by the corresponding parkin gene. It exhibits ubiquitin-protein ligase activity. In this review, we analyze domain structure, substrate specificity, subcellular localization of parkin, and regulation of its activity. Then we discuss data on the effects of various mutations in the parkin gene on structure and functions of this protein and results obtained with parkin knock-out animals. Better understanding of parkin biochemistry, its compartmentalization, functions, and altered functions would help the development of new approaches for the treatment of both inherited and sporadic cases of Parkinson’s disease.
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Abbreviations
- CDCrel-1:
-
cell division control-related protein
- CHIP:
-
C-terminus Hsp 70-interacting protein
- EPR:
-
endoplasmic reticulum
- Hsp 70:
-
heat shock protein 70 kD
- IBR:
-
inbetween RING-site
- MAO:
-
monoamine oxidase
- Pael-R:
-
parkin-associated endothelial-like receptor
- PD:
-
Parkinson’s disease
- RING:
-
really interesting gene
- UBL-domain:
-
ubiquitin-like domain
- UCL-L1:
-
ubiquitin carboxy-terminal hydrolase L1
- UPD-domain:
-
unique parkin domain.
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Published in Russian in Biokhimiya, 2006, Vol. 71, No. 8, pp. 1050–1061.
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Buneeva, O.A., Medvedev, A.E. Ubiquitin-protein ligase parkin and its role in the development of Parkinson’s disease. Biochemistry (Moscow) 71, 851–860 (2006). https://doi.org/10.1134/S0006297906080050
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DOI: https://doi.org/10.1134/S0006297906080050