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Ubiquitin-protein ligase parkin and its role in the development of Parkinson’s disease

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Abstract

Parkin is a protein encoded by the corresponding parkin gene. It exhibits ubiquitin-protein ligase activity. In this review, we analyze domain structure, substrate specificity, subcellular localization of parkin, and regulation of its activity. Then we discuss data on the effects of various mutations in the parkin gene on structure and functions of this protein and results obtained with parkin knock-out animals. Better understanding of parkin biochemistry, its compartmentalization, functions, and altered functions would help the development of new approaches for the treatment of both inherited and sporadic cases of Parkinson’s disease.

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Abbreviations

CDCrel-1:

cell division control-related protein

CHIP:

C-terminus Hsp 70-interacting protein

EPR:

endoplasmic reticulum

Hsp 70:

heat shock protein 70 kD

IBR:

inbetween RING-site

MAO:

monoamine oxidase

Pael-R:

parkin-associated endothelial-like receptor

PD:

Parkinson’s disease

RING:

really interesting gene

UBL-domain:

ubiquitin-like domain

UCL-L1:

ubiquitin carboxy-terminal hydrolase L1

UPD-domain:

unique parkin domain.

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Correspondence to A. E. Medvedev.

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Published in Russian in Biokhimiya, 2006, Vol. 71, No. 8, pp. 1050–1061.

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Buneeva, O.A., Medvedev, A.E. Ubiquitin-protein ligase parkin and its role in the development of Parkinson’s disease. Biochemistry (Moscow) 71, 851–860 (2006). https://doi.org/10.1134/S0006297906080050

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