Annals of Biomedical Engineering

, Volume 32, Issue 11, pp 1494–1503

Mechanical Analysis of Atherosclerotic Plaques Based on Optical Coherence Tomography

Authors

  • Alexandra H. Chau
    • Department of Mechanical Engineering and Biological Engineering DivisionMassachusetts Institute of Technology
    • Wellman Center for Photomedicine, Massachusetts General HospitalHarvard Medical School
  • Raymond C. Chan
    • Wellman Center for Photomedicine, Massachusetts General HospitalHarvard Medical School
  • Milen Shishkov
    • Wellman Center for Photomedicine, Massachusetts General HospitalHarvard Medical School
  • Briain MacNeill
    • Wellman Center for Photomedicine, Massachusetts General HospitalHarvard Medical School
  • Nicusor Iftimia
    • Wellman Center for Photomedicine, Massachusetts General HospitalHarvard Medical School
  • Guillermo J. Tearney
    • Wellman Center for Photomedicine, Massachusetts General HospitalHarvard Medical School
  • Roger D. Kamm
    • Department of Mechanical Engineering and Biological Engineering DivisionMassachusetts Institute of Technology
  • Brett E. Bouma
    • Wellman Center for Photomedicine, Massachusetts General HospitalHarvard Medical School
  • Mohammad R. Kaazempur-Mofrad
    • Department of Mechanical Engineering and Biological Engineering DivisionMassachusetts Institute of Technology
Article

DOI: 10.1114/B:ABME.0000049034.75368.4a

Cite this article as:
Chau, A.H., Chan, R.C., Shishkov, M. et al. Annals of Biomedical Engineering (2004) 32: 1494. doi:10.1114/B:ABME.0000049034.75368.4a

Abstract

Finite element analysis is a powerful tool for investigating the biomechanics of atherosclerosis and has thereby provided an improved understanding of acute myocardial infarction. Structural analysis of arterial walls is traditionally performed using geometry contours derived from histology. In this paper we demonstrate the first use of a new imaging technique, optical coherence tomography (OCT), as a basis for finite element analysis. There are two primary benefits of OCT relative to histology: 1) imaging is performed without excessive tissue handling, providing a more realistic geometry than histology and avoiding structural artifacts common to histologic processing, and 2) OCT imaging can be performed in vivo, making it possible to study disease progression and the effect of therapeutic treatments in animal models and living patients. Patterns of mechanical stress and strain distributions computed from finite element analysis based on OCT were compared with those from modeling based on “gold standard” histology. Our results indicate that vascular structure and composition determined by OCT provides an adequate basis for investigating the biomechanical factors relevant to atherosclerosis and acute myocardial infarction.

Optical coherence tomography (OCT)FEMAtherosclerotic plaques

Copyright information

© Biomedical Engineering Society 2004