Annals of Biomedical Engineering

, Volume 31, Issue 10, pp 1182-1193

Effect of Stenosis Asymmetry on Blood Flow and Artery Compression: A Three-Dimensional Fluid-Structure Interaction Model

  • Dalin TangAffiliated withMathematical Sciences Department, Worcester Polytechnic Institute
  • , Chun YangAffiliated withMathematics Department, Beijing Normal University
  • , Shunichi KobayashiAffiliated withDepartment of Functional Machinery and Mechanics, Shinshu University
  • , Jie ZhengAffiliated withMallinkcrodt Institute of Radiology, Washington University School of Medicine
  • , Raymond P. VitoAffiliated withSchool of Mechanical Engineering, Georgia Institute of Technology

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A nonlinear three-dimensional thick-wall model with fluid-structure interactions is introduced to simulate blood flow in carotid arteries with an asymmetric stenosis to quantify the effects of stenosis severity, eccentricity, and pressure conditions on blood flow and artery compression (compressive stress in the wall). Mechanical properties of the tube wall are measured using a thick-wall stenosis model made of polyvinyl alcohal hydrogel whose mechanical properties are close to that of carotid arteries. A hyperelastic Mooney–Rivlin model is used to implement the experimentally measured nonlinear elastic properties of the tube wall. A 36.5% pre-axial stretch is applied to make the simulation physiological. The Navier–Stokes equations in curvilinear form are used for the fluid model. Our results indicate that severe stenosis causes critical flow conditions, high tensile stress, and considerable compressive stress in the stenosis plaque which may be related to artery compression and plaque cap rupture. Stenosis asymmetry leads to higher artery compression, higher shear stress and a larger flow separation region. Computational results are verified by available experimental data. © 2003 Biomedical Engineering Society.

PAC2003: 8719Uv, 8710+e

Stroke Heart attack Plaque cap rupture Collapsible Finite difference Fluid-structure interaction Nonlinear elasticity Iterative Generalized finite difference