Lung Area–Volume Models in Relation to the Recruitment–Derecruitment of Individual Lung Units
Rent the article at a discountRent now
* Final gross prices may vary according to local VAT.Get Access
The objective of this study was to reconsider some of the previous experimental results in terms of simple geometric models in order to determine if any of the apparent conflicts could be explained within a more unified concept. These models allow individual lung units and the entire lung to expand differently with regard to their area–volume relationship. The effect of a recruitment–derecruitment process as the lung inflates–deflates is also considered. Examples are used to illustrate how some of the apparent conflicts found in the literature may arise from whether or not recruitment and derecruitment take place during lung expansion and contraction. © 2001 Biomedical Engineering Society.
PAC01: 8719Uv, 8710+e
- Aherne, W. Methods of counting discrete issue components in microscopical sections. J. R. Microsc. Soc. 87:493, 1967.
- Akahori, T., S. Suzuki, M. Suzuki, and T. Okubo. Dynamic behavior of alveolar surface-to-volume ratio on live dogs by light-scattering stereology. J. Appl. Physiol. 75:1624–1629, 1993.
- Ardila, R., T. Horie, and J. Hildebrandt. Microscopic isotropy of lung expansion. Respir. Physiol. 20:105–115, 1979.
- Bachofen, H., and J. Hildebrandt. Area analysis of pressure– volume hysteresis in mammalian lungs. J. Appl. Physiol. 30:493–497, 1971.
- Bachofen, H., S. Schürch, M. Urbinelli, and E. R. Weibel. Relations among alveolar surface tension, surface area, volume, and recoil pressure. J. Appl. Physiol. 62:1878–1887, 1987.
- Boyles, III, J., E. S. Engelstein, and L. I. Sinoway. Mean air space diameter, lung surface area, and alveolar surface tension. Respiration 34:241–249, 1977.
- Daly, B. D., G. E. Parks, C. H. Edmonds, C. W. Hibbs, and J. C. Normal. Dynamic alveolar mechanics as studied by video microscopy. Respir. Physiol. 24:217–323, 1976.
- D'Angelo, E. Local alveolar size and transpulmonary pressure in situ and in isolated lungs. Respir. Physiol. 14:251–266, 1972.
- Dunnil, M. S. Effects of lung inflation on alveolar surface area in the dog. Nature (London) 214:1013–1014, 1967.
- Faridy, E. E., and S. Permut. Surface forces and airway obstruction. J. Appl. Physiol. 30:319–321, 1971.
- Flicker, E., and J. Lee. Equilibrium of force on subpleural alveoli: Implication to lung mechanics. J. Appl. Physiol. 36:366–374, 1974.
- Forrest, J. B. The effect of changes in lung volume on the size and shape of alveoli. J. Physiol. (London) 210:533–547, 1970.
- Frazer, D. G., and K. C. Weber. Trapped air in ventilated excised rats lungs. J. Appl. Physiol. 40:915–922, 1976.
- Frazer, D. G., P. W. Stengel, and K. C. Weber. Meniscus formation in airways of excised rat lungs. Respir. Physiol. 36:121–129, 1979.
- Frazer, D. G., and G. N. Franz. Trapped gas and lung hysteresis. Respir. Physiol. 46:237–246, 1981.
- Frazer, D. G., L. D. Smith, L. R. Brancazio, and K. C. Weber. Comparison of lung sounds and gas trapping in the study of airway mechanics. Environ. Health Perspect. 66:25–30, 1986.
- Frazer, D. G., K. C. Weber, and G. N. Franz. Evidence of sequential opening and closing of lung units during inflation–deflation of excised rat lungs. Respir. Physiol. 61:277–288, 1985.
- Gil, J., and E. R. Weibel. Morphological study of pressure– volume hysteresis in lungs fixed by vascular perfusion. Respir. Physiol. 15:190–213, 1972.
- Gil, J., H. Bachofen, P. Gehr, and E. R. Weibel. Alveolar volume–surface area relationship in air-and saline-filled lungs fixed by vascular perfusion. J. Appl. Physiol.: Respir., Environ. Exercise Physiol. 47:990–1001, 1979.
- Hills, B. A. Geometric irreversibility and compliance hysteresis in the lung. Respir. Physiol. 13:50–61, 1971.
- Klingele, T. G., and N. C. Staub. Alveolar shape change with volume in isolated, air-filled lobes of cat lung. J. Appl. Physiol. 28:411–419, 1970.
- Kuno, K., and N. C. Staub. Acute mechanical effects of lung volume changes on artificial microholes in alveolar walls. J. Appl. Physiol. 24:83–92, 1968.
- Lum, H., and W. Mitzner. A species comparison of alveolar size and surface forces. J. Appl. Physiol. 62:1865–1871, 1987.
- Macklem, P. T. Respiratory mechanics. Annu. Rev. Physiol. 40:157–184, 1978.
- Mercer, R. R., J. M. Laco, and J. D. Crapo. Threedimensional reconstructon of alveoli in the rat lung for pressure–volume relationships. J. Appl. Physiol. 62:1480–1487, 1987.
- Nieman, G. F. Mechanisms of lung expansion: A review. Resp. Care 28:426–433, 1983.
- Smaldone, G. C., W. Mitzner, and H. Itoh. Role of alveolar recruitment in lung inflation: Influence on pressure–volume hysteresis. J. Appl. Physiol.: Respir., Environ. Exercise Physiol. 55:1321–1332, 1983.
- Smith, L. D., D. G. Frazer, and W. L. Cooley. The spectral analysis of tracheal lung sounds in ventilated excised rat lungs. In: 27th Midwest Symposium on Circuits and Systems, edited by R. E. Swartwout. 1984, Vol. 1, p. 13–16.
- Suzuki, S., J. P. Butler, E. H. Oldmixon, and F. G. Hoppin, Jr. Light scattering by lung correlates with stereological measurements. J. Appl. Physiol. 58:97–104, 1985.
- Weibel, E. R. Morphometry of the Human Lung. New York: Academic, 1963.
- Weibel, E. R. Stereological Methods. London: Academic, 1980, Vol. 2.
- Weibel, E. R., and D. M. Gomez. A principle for counting tissue random sections. J. Appl. Physiol. 17:343–348, 1962.
- Lung Area–Volume Models in Relation to the Recruitment–Derecruitment of Individual Lung Units
Annals of Biomedical Engineering
Volume 29, Issue 3 , pp 252-262
- Cover Date
- Print ISSN
- Online ISSN
- Kluwer Academic Publishers-Plenum Publishers
- Additional Links
- Geometric irreversibility of the lung
- Lung area–volume models
- Lung units
- Lung expansion
- Lung mechanics
- Industry Sectors
- Author Affiliations
- 1. Department of Obstetrics and Gynecology, West Virginia University School of Medicine, Morgantown, WV
- 2. Department of Physiology, West Virginia University School of Medicine, Morgantown, WV
- 3. Division of Respiratory Diseases, National Institute for Occupational Safety and Health, Morgantown, WV
- 4. Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV