Journal of General Internal Medicine

, Volume 19, Issue 4, pp 380–389

Effect of supplemental vitamin E for the prevention and treatment of cardiovascular disease

Authors

    • the Southern California Evidence-Based Practice CenterRand Corporation
    • Greater Los Angeles VA Healthcare System
  • Sally C. Morton
    • the Southern California Evidence-Based Practice CenterRand Corporation
  • Lara K. Jungvig
    • the Southern California Evidence-Based Practice CenterRand Corporation
  • Jay Udani
    • Northridge Hospital Integrative Medicine Program
    • UCLA/Geffen School of Medicine
  • Myles Spar
    • UCLA School of Medicine
  • Wenli Tu
    • the Southern California Evidence-Based Practice CenterRand Corporation
  • Marika J. Suttorp
    • the Southern California Evidence-Based Practice CenterRand Corporation
  • Ian Coulter
    • the Southern California Evidence-Based Practice CenterRand Corporation
  • Sydne J. Newberry
    • the Southern California Evidence-Based Practice CenterRand Corporation
  • Mary Hardy
    • the Southern California Evidence-Based Practice CenterRand Corporation
    • Cedars-Sinai Medical Center
Review

DOI: 10.1111/j.1525-1497.2004.30090.x

Cite this article as:
Shekelle, P.G., Morton, S.C., Jungvig, L.K. et al. J GEN INTERN MED (2004) 19: 380. doi:10.1111/j.1525-1497.2004.30090.x

Abstract

OBJECTIVE: To evaluate and synthesize the evidence on the effect of supplements of vitamin E on the prevention and treatment of cardiovascular disease.

DESIGN: Systematic review of placebo-controlled randomized controlled trials; meta-analysis where justified.

MEASUREMENTS AND MAIN RESULTS: Eighty-four eligible trials were identified. For the outcomes of all-cause mortality, cardiovascular mortality, fatal or nonfatal myocardial infarction, and blood lipids, neither supplements of vitamin E alone nor vitamin E given with other agents yielded a statistically significant beneficial or adverse pooled relative risk (for example, pooled relative risk of vitamin E alone=0.96 [95% confidence interval (CI), 0.84 to 1.10]; 0.97 [95% CI, 0.80 to 1.90]; and 0.72 [95% CI, 0.51 to 1.02] for all-cause mortality, cardiovascular mortality, and nonfatal myocardial infarction, respectively.

CONCLUSIONS: There is good evidence that vitamin E supplementation does not beneficially or adversely affect cardiovascular outcomes.

Key words

vitamin Eantioxidantsmeta-analysissystematic reviewcardiovascular disease

Copyright information

© Society of General Internal Medicine 2004