Effect of supplemental vitamin E for the prevention and treatment of cardiovascular disease
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OBJECTIVE: To evaluate and synthesize the evidence on the effect of supplements of vitamin E on the prevention and treatment of cardiovascular disease.
DESIGN: Systematic review of placebo-controlled randomized controlled trials; meta-analysis where justified.
MEASUREMENTS AND MAIN RESULTS: Eighty-four eligible trials were identified. For the outcomes of all-cause mortality, cardiovascular mortality, fatal or nonfatal myocardial infarction, and blood lipids, neither supplements of vitamin E alone nor vitamin E given with other agents yielded a statistically significant beneficial or adverse pooled relative risk (for example, pooled relative risk of vitamin E alone=0.96 [95% confidence interval (CI), 0.84 to 1.10]; 0.97 [95% CI, 0.80 to 1.90]; and 0.72 [95% CI, 0.51 to 1.02] for all-cause mortality, cardiovascular mortality, and nonfatal myocardial infarction, respectively.
CONCLUSIONS: There is good evidence that vitamin E supplementation does not beneficially or adversely affect cardiovascular outcomes.
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- Effect of supplemental vitamin E for the prevention and treatment of cardiovascular disease
Journal of General Internal Medicine
Volume 19, Issue 4 , pp 380-389
- Cover Date
- Print ISSN
- Online ISSN
- Additional Links
- vitamin E
- systematic review
- cardiovascular disease
- Industry Sectors
- Author Affiliations
- 1. the Southern California Evidence-Based Practice Center, Rand Corporation, Santa Monica, Calif
- 2. Greater Los Angeles VA Healthcare System, Los Angeles, Calif
- 3. Northridge Hospital Integrative Medicine Program, Los Angeles, Calif
- 4. UCLA/Geffen School of Medicine, Los Angeles, Calif
- 5. UCLA School of Medicine, Los Angeles, Calif
- 6. Cedars-Sinai Medical Center, Los Angeles, Calif