Review

Journal of General Internal Medicine

, Volume 19, Issue 4, pp 380-389

First online:

Effect of supplemental vitamin E for the prevention and treatment of cardiovascular disease

  • Paul G. ShekelleAffiliated withthe Southern California Evidence-Based Practice Center, Rand CorporationGreater Los Angeles VA Healthcare System Email author 
  • , Sally C. MortonAffiliated withthe Southern California Evidence-Based Practice Center, Rand Corporation
  • , Lara K. JungvigAffiliated withthe Southern California Evidence-Based Practice Center, Rand Corporation
  • , Jay UdaniAffiliated withNorthridge Hospital Integrative Medicine ProgramUCLA/Geffen School of Medicine
  • , Myles SparAffiliated withUCLA School of Medicine
  • , Wenli TuAffiliated withthe Southern California Evidence-Based Practice Center, Rand Corporation
  • , Marika J. SuttorpAffiliated withthe Southern California Evidence-Based Practice Center, Rand Corporation
  • , Ian CoulterAffiliated withthe Southern California Evidence-Based Practice Center, Rand Corporation
  • , Sydne J. NewberryAffiliated withthe Southern California Evidence-Based Practice Center, Rand Corporation
    • , Mary HardyAffiliated withthe Southern California Evidence-Based Practice Center, Rand CorporationCedars-Sinai Medical Center

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Abstract

OBJECTIVE: To evaluate and synthesize the evidence on the effect of supplements of vitamin E on the prevention and treatment of cardiovascular disease.

DESIGN: Systematic review of placebo-controlled randomized controlled trials; meta-analysis where justified.

MEASUREMENTS AND MAIN RESULTS: Eighty-four eligible trials were identified. For the outcomes of all-cause mortality, cardiovascular mortality, fatal or nonfatal myocardial infarction, and blood lipids, neither supplements of vitamin E alone nor vitamin E given with other agents yielded a statistically significant beneficial or adverse pooled relative risk (for example, pooled relative risk of vitamin E alone=0.96 [95% confidence interval (CI), 0.84 to 1.10]; 0.97 [95% CI, 0.80 to 1.90]; and 0.72 [95% CI, 0.51 to 1.02] for all-cause mortality, cardiovascular mortality, and nonfatal myocardial infarction, respectively.

CONCLUSIONS: There is good evidence that vitamin E supplementation does not beneficially or adversely affect cardiovascular outcomes.

Key words

vitamin E antioxidants meta-analysis systematic review cardiovascular disease