Short-term exposure of female rats to industrial metal salts: Effect on implantation and pregnancy
Rent the article at a discountRent now
* Final gross prices may vary according to local VAT.Get Access
The objective of this study was to characterize the adverse effects of industrial metal salts during the early stages of pregnancy.
Successfully mated female rats were exposed to the following metal salts via intragastric intubation; manganese sulfate, lead acetate, aluminum chloride, ferrous chloride and ferric chloride in doses of 50 mg/kg body weight and chromium chloride and potassium dichromate in doses of 25 mg/kg body weight on days l–3 or 4–6 of pregnancy. Female rats were killed on day 20 of gestation and the pregnancy outcome was determined.
The administration of manganese sulfate, chromium chloride, potassium dichromate and ferric chloride to female rats on days 1–3 of pregnancy caused pregnancy failure. However, the administration of manganese sulfate and potassium dichromate reduced the number of implantations. The administration of manganese sulfate, potassium dichromate and ferric chloride reduced the number of viable fetuses. The total number of resorptions increased in the lead acetate, aluminum chloride, ferrous chloride and ferric chloride exposed groups. In contrast, the administration of manganese sulfate, aluminum chloride and ferric chloride on days 4–6 of pregnancy caused pregnancy failure. However, the administration of ferric chloride reduced the number of implantations. The administration of manganese sulfate, aluminum chloride, potassium dichromate, ferrous chloride and ferric chloride reduced the number of viable fetuses. The total number of resorptions increased in the manganese sulfate, lead acetate, aluminum chloride, potassium dichromate, ferrous chloride and ferric chloride exposed groups.
This work demonstrates that the short-term exposure of female rats to industrial metal salts during the early stages of gestation would cause failure of pregnancy and produce fetotoxic or fetal resorptive potentials.
- Kumar, S (2004) Occupational exposure associated with reproductive dysfunction. J Occup Health 46: pp. 1-19 CrossRef
- Marco, M, Halpern, R, Barros, HM (2005) Early behavioral effects of lead perinatal exposure in rat pups. Toxicology 211: pp. 49-58 CrossRef
- Klein, M, Kaminsky, P, Barbe, F, Duc, M (1994) Lead poisoning in pregnancy. Press Med 23: pp. 576-580
- Shmitova, LA (1980) Content of hexavalent chromium in biological substrates of pregnant women in the immediate postnatal period engaged in the manufacture of chromium compounds. Gigtrud Prof Zabol 2: pp. 33-35
- Markarov YV, Shmitova LA. Occupational conditions and gynecological illness in workers engaged in the production compounds. In: Dixon RL, ed. Symposium on Target Organ Toxicity: Gonads. Environ Health Perspect 1978; 24: 1–128.
- Lewis, M, Worobey, J, Ramsay, DS, McCormack, MK (1992) Prenatal exposure to heavy metals: effect on childhood cognitive skills and health status. Pediatrics 89: pp. 1010-1015
- Andrews, KW, Savits, DA, Hertz-Piciotto, I (1994) Prenatal lead exposure in relation to gestational age and birth weight: a review of epidemiologic studies. Am J Ind Med 26: pp. 12-32 CrossRef
- Odenbro, A, Kihlström, JE (1977) Frequency of pregnancy and ova implantation in triethyl lead-treated mice. Toxicol Appl Pharmacol 39: pp. 359-363 CrossRef
- Bennett, RW, Prersaud, TVN, Moore, KL (1975) Experimental studies on the effects of aluminum on pregnancy and fetal development. Anat Anz Bd 138: pp. S365-S378
- Wide, M (1984) Effect of short-term exposure to five industrial metals on the embryonic and fetal development of the mouse. Environ Res 33: pp. 47-53 CrossRef
- Ganrot, PO (1986) Metabolism and possible health effects of aluminum. Environ Health Perspect 65: pp. 363-441 CrossRef
- Cummings, AM (1990) Toxicological mechanisms of implantation failure. Fundam Appl Toxicol 15: pp. 571-579 CrossRef
- Siegel, S (1956) Non-Parametric Statistics for the Behavioural Sciences. McGraw-Hill, London
- Beaudoin, AR Embryology and teratology. In: Baker, HJ, Lindsey, JR, Weisbroth, SH eds. (1980) The Laboratory Rat: Vol. 2. Research Application. Academic Press, NewYork, pp. 75-94
- McCormack, JJ, GreenWald, GS (1974) Evidence for a preimplantation rise in oestradiol-17β levels on day 4 of pregnancy in the mouse. J Reprod Fertil 41: pp. 297-301 CrossRef
- Hodgen, AD, Itskovitz, J Recognition and maintenance of pregnancy. In: Knobil, E, Neill, J eds. (1988) The Physiology of Reproduction. Raven Press, NewYork, pp. 1995-2001
- Vallee, BL, Ulmer, DD (1972) Biochemical effect of mercury, cadmium and lead. Ann Rev Biochem 41: pp. 19-28
- Tabacova, S, Little, RE, Balabaeva, L, Pavlova, S, Petrov, I (1994) Complication of pregnancy in relation to maternal lipid peroxidation, glutathione and exposure to metals. Reprod Toxicol 3: pp. 217-224 CrossRef
- Jacquet, P, Draye, JP (1982) Toxicity of chromium salts to cultured mouse embryos. Toxicol Lett 12: pp. 53-57 CrossRef
- Bataineh, H, Al-Hamood, MH, Elbetieha, A, Bani, Hani I (1997) Effect of long-term ingestion of chromium compounds on aggression: sex behavior and fertility in adult male rat. Drug Chem Toxicol 20: pp. 133-149 CrossRef
- Anane, R, Bonini, M, Creppy, EE (1997) Transplacental passage of aluminum from pregnant mice to fetal organs after maternal transcutanous exposure. Human Experim Toxicol 16: pp. 501-504 CrossRef
- Short-term exposure of female rats to industrial metal salts: Effect on implantation and pregnancy
Reproductive Medicine and Biology
Volume 6, Issue 3 , pp 179-183
- Cover Date
- Print ISSN
- Online ISSN
- Additional Links
- industrial metal salts
- pregnancy failure
- Author Affiliations
- 1. Department of Physiology, Jordan University of Science and Technology, Irbid
- 2. Faculty of Medicine, Department of Anatomy, Jordan University of Science and Technology, 22110, Irbid, Jordan
- 3. Department of Biology, Faculty of Agriculture and Science, Jarash Private University, Jarash, Jordan