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Short-term exposure of female rats to industrial metal salts: Effect on implantation and pregnancy

Reproductive Medicine and Biology

Abstract

Aim

The objective of this study was to characterize the adverse effects of industrial metal salts during the early stages of pregnancy.

Methods

Successfully mated female rats were exposed to the following metal salts via intragastric intubation; manganese sulfate, lead acetate, aluminum chloride, ferrous chloride and ferric chloride in doses of 50 mg/kg body weight and chromium chloride and potassium dichromate in doses of 25 mg/kg body weight on days l–3 or 4–6 of pregnancy. Female rats were killed on day 20 of gestation and the pregnancy outcome was determined.

Results

The administration of manganese sulfate, chromium chloride, potassium dichromate and ferric chloride to female rats on days 1–3 of pregnancy caused pregnancy failure. However, the administration of manganese sulfate and potassium dichromate reduced the number of implantations. The administration of manganese sulfate, potassium dichromate and ferric chloride reduced the number of viable fetuses. The total number of resorptions increased in the lead acetate, aluminum chloride, ferrous chloride and ferric chloride exposed groups. In contrast, the administration of manganese sulfate, aluminum chloride and ferric chloride on days 4–6 of pregnancy caused pregnancy failure. However, the administration of ferric chloride reduced the number of implantations. The administration of manganese sulfate, aluminum chloride, potassium dichromate, ferrous chloride and ferric chloride reduced the number of viable fetuses. The total number of resorptions increased in the manganese sulfate, lead acetate, aluminum chloride, potassium dichromate, ferrous chloride and ferric chloride exposed groups.

Conclusion

This work demonstrates that the short-term exposure of female rats to industrial metal salts during the early stages of gestation would cause failure of pregnancy and produce fetotoxic or fetal resorptive potentials.

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References

  1. Kumar S. Occupational exposure associated with reproductive dysfunction. J Occup Health 2004; 46: 1–19.

    Article  PubMed  CAS  Google Scholar 

  2. De Marco M, Halpern R, Barros HM. Early behavioral effects of lead perinatal exposure in rat pups. Toxicology 2005; 211: 49–58.

    Article  PubMed  CAS  Google Scholar 

  3. Klein M, Kaminsky P, Barbe F, Duc M. Lead poisoning in pregnancy. Press Med 1994; 23: 576–580.

    CAS  Google Scholar 

  4. Shmitova LA. Content of hexavalent chromium in biological substrates of pregnant women in the immediate postnatal period engaged in the manufacture of chromium compounds. Gigtrud Prof Zabol 1980; 2: 33–35.

    Google Scholar 

  5. Markarov YV, Shmitova LA. Occupational conditions and gynecological illness in workers engaged in the production compounds. In: Dixon RL, ed. Symposium on Target Organ Toxicity: Gonads. Environ Health Perspect 1978; 24: 1–128.

  6. Lewis M, Worobey J, Ramsay DS, McCormack MK. Prenatal exposure to heavy metals: effect on childhood cognitive skills and health status. Pediatrics 1992; 89: 1010–1015.

    PubMed  CAS  Google Scholar 

  7. Andrews KW, Savits DA, Hertz-Piciotto I. Prenatal lead exposure in relation to gestational age and birth weight: a review of epidemiologic studies. Am J Ind Med 1994; 26: 12–32.

    Article  Google Scholar 

  8. Odenbro A, Kihlström JE. Frequency of pregnancy and ova implantation in triethyl lead-treated mice. Toxicol Appl Pharmacol 1977; 39: 359–363.

    Article  PubMed  CAS  Google Scholar 

  9. Bennett RW, Prersaud TVN, Moore KL. Experimental studies on the effects of aluminum on pregnancy and fetal development. Anat Anz Bd 1975; 138: S365-S378.

    Google Scholar 

  10. Wide M. Effect of short-term exposure to five industrial metals on the embryonic and fetal development of the mouse. Environ Res 1984; 33: 47–53.

    Article  PubMed  CAS  Google Scholar 

  11. Ganrot PO. Metabolism and possible health effects of aluminum. Environ Health Perspect 1986; 65: 363–441.

    Article  PubMed  CAS  Google Scholar 

  12. Cummings AM. Toxicological mechanisms of implantation failure. Fundam Appl Toxicol 1990; 15: 571–579.

    Article  PubMed  CAS  Google Scholar 

  13. Siegel S. Non-Parametric Statistics for the Behavioural Sciences. London: McGraw-Hill, 1956.

    Google Scholar 

  14. Beaudoin AR. Embryology and teratology. In: Baker HJ, Lindsey JR, Weisbroth SH, eds. The Laboratory Rat: Vol. 2. Research Application. NewYork: Academic Press, 1980; 75–94.

    Google Scholar 

  15. McCormack JJ, GreenWald GS. Evidence for a preimplantation rise in oestradiol-17β levels on day 4 of pregnancy in the mouse. J Reprod Fertil 1974; 41: 297–301.

    Article  PubMed  CAS  Google Scholar 

  16. Hodgen AD, Itskovitz J. Recognition and maintenance of pregnancy. In: Knobil E, Neill J, eds. The Physiology of Reproduction. NewYork: Raven Press, 1988; 1995–2001.

    Google Scholar 

  17. Vallee BL, Ulmer DD. Biochemical effect of mercury, cadmium and lead. Ann Rev Biochem 1972; 41: 19–28.

    Google Scholar 

  18. Tabacova S, Little RE, Balabaeva L, Pavlova S, Petrov I. Complication of pregnancy in relation to maternal lipid peroxidation, glutathione and exposure to metals. Reprod Toxicol 1994; 3: 217–224.

    Article  Google Scholar 

  19. Jacquet P, Draye JP. Toxicity of chromium salts to cultured mouse embryos. Toxicol Lett 1982; 12: 53–57.

    Article  PubMed  CAS  Google Scholar 

  20. Bataineh H, Al-Hamood MH, Elbetieha A, Bani Hani I. Effect of long-term ingestion of chromium compounds on aggression: sex behavior and fertility in adult male rat. Drug Chem Toxicol 1997; 20: 133–149.

    Article  PubMed  CAS  Google Scholar 

  21. Anane R, Bonini M, Creppy EE. Transplacental passage of aluminum from pregnant mice to fetal organs after maternal transcutanous exposure. Human Experim Toxicol 1997; 16: 501–504.

    Article  CAS  Google Scholar 

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Correspondence to Ziad M. Bataineh.

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Bataineh, H.N., Bataineh, Z.M. & Daradka, H. Short-term exposure of female rats to industrial metal salts: Effect on implantation and pregnancy. Reprod Med Biol 6, 179–183 (2007). https://doi.org/10.1111/j.1447-0578.2007.00183.x

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  • DOI: https://doi.org/10.1111/j.1447-0578.2007.00183.x

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