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On Recent Advances in Optimal Allocation Designs in Clinical Trials

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An Erratum to this article was published on 01 March 2014

Abstract

One of the fundamental questions in the design of clinical trials is how to optimally allocate treatments to study subjects to achieve selected experimental objectives. In this article we review major recent methodological advances in optimal allocation for clinical trials. A literature review shows that starting from the 2000s many new allocation methods have been proposed to enhance the design of multiobjective and multiarm clinical trials. These allocation designs can provide improvements over traditional balanced allocation designs both in terms of statistical efficiency and ethical criteria. We also discuss state-of-the art response-adaptive randomization procedures for implementing optimal allocation designs in practice.

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Authors and Affiliations

  1. Translational Sciences, Novartis Pharmaceuticals Corporation, East Hanover, New Jersey, USA

    Oleksandr Sverdlov

  2. Department of Statistics, George Mason University, 4400 University Drive, MS 4A7, Fairfax, Virginia, 22030, USA

    William F. Rosenberger

Authors
  1. Oleksandr Sverdlov
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  2. William F. Rosenberger
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Correspondence to William F. Rosenberger.

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Sverdlov, O., Rosenberger, W.F. On Recent Advances in Optimal Allocation Designs in Clinical Trials. J Stat Theory Pract 7, 753–773 (2013). https://doi.org/10.1080/15598608.2013.783726

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  • DOI: https://doi.org/10.1080/15598608.2013.783726

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