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Herpes simplex virus-1 and varicella-zoster virus latency in ganglia

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Abstract

Two human alpha-herpesviruses, herpes simplex virus (HSV)-1 and varicella zoster virus (VZV), account for the most frequent and serious neurologic disease caused by any of the eight human herpesviruses. Both HSV-1 and VZV become latent in ganglia. In this review, the authors describe features of latency for these viruses, such as distribution, prevalence, abundance, and configuration of viral DNA in latently infected human ganglia, as well as transcription, translation, and cell type infected. Studies of viral latency in animal models are also discussed. For each virus, remaining questions and future studies to understand the mechanism of latency are discussed with respect to prevention of serious cutaneous, ocular, and neurologic disease produced by virus reactivation.

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Authors and Affiliations

  1. Cullen Eye Institute, Department of Ophthalmology and Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA

    Bradley M. Mitchell

  2. Molecular Genetics and Microbiology, College of Medicine, University of Florida, Gainesville, Florida, USA

    David C. Bloom

  3. Department of Neurology, University of Colorado Health Sciences Center, 4200 East 9th Avenue, Mail Stop B182, 80262, Denver, CO, USA

    Randall J. Cohrs & Donald H. Gilden

  4. Department of Microbiology, University of Colorado Health Sciences Center, Denver, Colorado, USA

    Donald H. Gilden

  5. Department of Neurology, University of Glasgow, Institute of Neurological Sciences, Southern General Hospital NHS Trust, Glasgow, Scotland, UK

    Peter G. E. Kennedy

Authors
  1. Bradley M. Mitchell
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  2. David C. Bloom
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  3. Randall J. Cohrs
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  4. Donald H. Gilden
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  5. Peter G. E. Kennedy
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Corresponding author

Correspondence to Randall J. Cohrs.

Additional information

This work was supported in part by Public Health Service grants AI 48633 (DCB), NS 32623 (RJC, DHG), and AG 06127 (DHG) from the National Institutes of Health, and by the Wellcome Trust (PGEK).

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Mitchell, B.M., Bloom, D.C., Cohrs, R.J. et al. Herpes simplex virus-1 and varicella-zoster virus latency in ganglia. Journal of NeuroVirology 9, 194–204 (2003). https://doi.org/10.1080/13550280390194000

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  • DOI: https://doi.org/10.1080/13550280390194000

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