The Cerebellum

, Volume 5, Issue 2, pp 163–173

Purkinje cell death: Differences between developmental cell death and neurodegenerative death in mutant mice

  • Isabelle Dusart
  • Jean Louis Guenet
  • Constantino Sotelo
Original Article Scientific Papers

DOI: 10.1080/14734220600699373

Cite this article as:
Dusart, I., Guenet, J.L. & Sotelo, C. Cerebellum (2006) 5: 163. doi:10.1080/14734220600699373

Abstract

This review is devoted to Purkinje cell death occurring during development and in spontaneous cerebellar mutations of the mouse. We first present evidence in favor of an apoptotic developmental Purkinje cell death. Then, the different types of Purkinje cell degeneration occurring in mutant mice primarily affecting this neuronal population (nervous, purkinje cell degeneration, Lurcher, toppler, andwoozy) are described and discussed. In addition, we show, by reporting new data, that cell death intambaleante mutant mice can be related to autophagy. Last, we discuss the fact that the cell death pathways in mutant mice are more complex than the three types of developmental death generally described (apoptosis, autophagy, necrosis), since they share often characteristics of more than one type of these developmental cell deaths, particularly autophagy and apoptosis.

Key words

Purkinje cell apoptosis necrosis autophagy development 

Copyright information

© Springer 2006

Authors and Affiliations

  • Isabelle Dusart
    • 1
    • 2
  • Jean Louis Guenet
    • 3
  • Constantino Sotelo
    • 1
    • 2
    • 4
  1. 1.Universit’e Pierre et Marie Curie-Paris 6Paris
  2. 2.CNRSParisFrance
  3. 3.D’epartement de Biologie du D’eveloppementInstitut PasteurParisFrance
  4. 4.Catedra de Neurobiologia del Desarrollo, “Remedios Caro Almela”, Instituto de Neurociencias de AlicanteUniversidad Miguel Hernandez y CSICSant Joan d’Alacant, AlicanteSpain

Personalised recommendations