The Cerebellum

, 5:23

The puzzle of ploidy of Purkinje neurons


    • Institute of General PathologyUniversity of Milano
Scientific Papers

DOI: 10.1080/14734220500435894

Cite this article as:
Del Monte, U. Cerebellum (2006) 5: 23. doi:10.1080/14734220500435894


This paper places attention on the discrepancies existing in the literature on the ploidy of Purkinje neurons and focuses on the special case of partial replication of their genome and on the unequal frequency of polyploid Purkinje neurons in the cerebellar cortex of the lobes and the vermis. Owing to the compartmental structure of the cerebellum, this paper suggests the investigation with modern methods and techniques of other cerebellar regions such as the flocculus, with the aim of establishing whether increased ploidy correlates with cell hypertrophy and/or with stimulation of cerebellar functions.

Key words

Cerebellum Purkinje neurons (cells) polyploidy mammals humans

Copyright information

© Springer 2006