Journal of NeuroVirology

, Volume 14, Issue 5, pp 448–454

Serotonin receptor 2A blocker (risperidone) has no effect on human polyomavirus JC infection of primary human fetal glial cells

Authors

  • Moti L. Chapagain
    • Retrovirology Research Laboratory, Department of Tropical Medicine, Medical Microbiology and Pharmacology, Asia-Pacific Institute of Tropical Medicine and Infectious DiseasesJohn A. Burns School of Medicine
  • Laarni Sumibcay
    • Retrovirology Research Laboratory, Department of Tropical Medicine, Medical Microbiology and Pharmacology, Asia-Pacific Institute of Tropical Medicine and Infectious DiseasesJohn A. Burns School of Medicine
  • Ulziijargal Gurjav
    • Retrovirology Research Laboratory, Department of Tropical Medicine, Medical Microbiology and Pharmacology, Asia-Pacific Institute of Tropical Medicine and Infectious DiseasesJohn A. Burns School of Medicine
    • Molecular Biosciences and Bioengineering Graduate Program, College of Tropical Agriculture and Human ResourcesUniversity of Hawaii at Manoa
  • Pakieli H. Kaufusi
    • Retrovirology Research Laboratory, Department of Tropical Medicine, Medical Microbiology and Pharmacology, Asia-Pacific Institute of Tropical Medicine and Infectious DiseasesJohn A. Burns School of Medicine
  • Richard E. Kast
    • Department of PsychiatryUniversity of Vermont
    • Retrovirology Research Laboratory, Department of Tropical Medicine, Medical Microbiology and Pharmacology, Asia-Pacific Institute of Tropical Medicine and Infectious DiseasesJohn A. Burns School of Medicine
    • Molecular Biosciences and Bioengineering Graduate Program, College of Tropical Agriculture and Human ResourcesUniversity of Hawaii at Manoa
Short Communication

DOI: 10.1080/13550280802235916

Cite this article as:
Chapagain, M.L., Sumibcay, L., Gurjav, U. et al. Journal of NeuroVirology (2008) 14: 448. doi:10.1080/13550280802235916

Abstract

A recent report demonstrated that JC virus (JCV) employs serotonin receptor 2A (5HT2AR) to infect the glial cells. To assess the ability of a potent 5HT2AR blocker, risperidone, to inhibit JCV infection, the authors treated primary human fetal glial (PHFG) cells in vitro with risperidone for 24 h and inoculated with JCV(Mad1). There was no significant difference in JCV genome copies or mRNA transcripts and protein expression in treatment-naïve and risperidone-treated PHFG cells. These data indicate that risperidone does not inhibit JCV(Mad1) attachment, internalisation, and replication in PHFG cells, and 5HT2AR blockers may not be effective in treating progressive multifocal leukoencephalopathy (PML).

Keywords

JCVhuman polyomavirusPMLserotonin receptorrisperidonemirtazapine
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Copyright information

© Journal of NeuroVirology, Inc. 2008