Journal of NeuroVirology

, Volume 15, Supplement 1, pp 14–24

Further characterization of the spatial learning deficit in the human immunodeficiency virus-1 transgenic rat

  • Abigail L. Lashomb
  • Michael Vigorito
  • Sulie L. Chang
Article

DOI: 10.1080/13550280802232996

Cite this article as:
Lashomb, A.L., Vigorito, M. & Chang, S.L. Journal of NeuroVirology (2009) 15(Suppl 1): 14. doi:10.1080/13550280802232996

Abstract

Human immunodeficiency virus (HIV)-associated dementia (HAD) encompasses a spectrum of cognitive and motor deficits resulting from the progression of central nervous system abnormalities caused by the HIV-1 virus. With the advent of highly active antiretroviral therapy (HAART), these deficits have become milder, but more prevalent as the population of HIV-positive individuals ages. Mild impairment in cognition has also been identified in asymptomatic HIV-1 patients. The noninfectious HIV-1 transgenic (Tg) rat recently developed to study the pathogenesis of acquired immunodeficiency syndrome (AIDS) may also be useful for the study of the early and chronic effects of HIV-1 on learning and cognition. In a previous study, we demonstrated that HIV-1Tg rats show a deficit in learning how to swim to a hidden platform in a modified water maze task compared to normal and transgenic controls. In the present study, we replicate this result and demonstrate that HIV-1Tg rats also show a significant deficit in reversal learning and new strategy learning. These results indicate that the HIV-1Tg rat is a promising model in which to study the neuropathogenic mechanisms that can cause cognitive deficits in patients with HAD as well as asymptomatic HIV-positive individuals.

Keywords

behavior HIV-1Tg rat learning 

Copyright information

© Journal of NeuroVirology, Inc. 2009

Authors and Affiliations

  • Abigail L. Lashomb
    • 1
  • Michael Vigorito
    • 1
  • Sulie L. Chang
    • 2
    • 3
  1. 1.Department of PsychologySeton Hall UniversitySouth OrangeUSA
  2. 2.Institute of NeuroImmune Pharmacology and Department of Biological SciencesSeton Hall UniversitySouth OrangeUSA
  3. 3.Department of Biological SciencesSeton Hall UniversitySouth OrangeUSA

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