Journal of NeuroVirology

, Volume 13, Issue 5, pp 477–481

Herpes simplex encephalitis presenting with exclusively frontal lobe involvement


  • Sean W. Taylor
    • Department of Medicine (Neurology)Queen’s University
  • Donald H. Lee
    • Departments of Radiology and Nuclear MedicineUniversity of Western Ontario
    • Department of Medicine (Neurology)Queen’s University
    • Health Sciences Centre, GF543
Case Report

DOI: 10.1080/13550280701491131

Cite this article as:
Taylor, S.W., Lee, D.H. & Jackson, A.C. Journal of NeuroVirology (2007) 13: 477. doi:10.1080/13550280701491131


The authors report a patient with herpes simplex encephalitis who presented with magnetic resonance imaging (MRI) lesions exclusively in the frontal lobes, including the bilateral anterior cingulate gyri. She is making a good recovery after therapy with intravenous acyclovir. A similar presentation with a fatal outcome was previously reported by Rose et al (Neurology 42: 1809–1812, 1992). MRI shows temporal lesions in most patients with herpes simplex encephalitis, whereas occasional patients have normal imaging. A high index of suspicion for the diagnosis of herpes simplex encephalitis should be maintained when a patient presents with fever and brain lesions involving extratemporal limbic system structures.


cingulate gyrusencephalitisfrontal lobeherpes simplex virus
Download to read the full article text

Copyright information

© Journal of NeuroVirology, Inc. 2007