Case Report

Journal of NeuroVirology

, Volume 13, Issue 5, pp 477-481

Herpes simplex encephalitis presenting with exclusively frontal lobe involvement

  • Sean W. TaylorAffiliated withDepartment of Medicine (Neurology), Queen’s University
  • , Donald H. LeeAffiliated withDepartments of Radiology and Nuclear Medicine, University of Western Ontario
  • , Alan C. JacksonAffiliated withDepartment of Medicine (Neurology), Queen’s UniversityHealth Sciences Centre, GF543 Email author 

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The authors report a patient with herpes simplex encephalitis who presented with magnetic resonance imaging (MRI) lesions exclusively in the frontal lobes, including the bilateral anterior cingulate gyri. She is making a good recovery after therapy with intravenous acyclovir. A similar presentation with a fatal outcome was previously reported by Rose et al (Neurology 42: 1809–1812, 1992). MRI shows temporal lesions in most patients with herpes simplex encephalitis, whereas occasional patients have normal imaging. A high index of suspicion for the diagnosis of herpes simplex encephalitis should be maintained when a patient presents with fever and brain lesions involving extratemporal limbic system structures.


cingulate gyrus encephalitis frontal lobe herpes simplex virus