Journal of NeuroVirology

, Volume 13, Issue 5, pp 477–481

Herpes simplex encephalitis presenting with exclusively frontal lobe involvement

  • Sean W. Taylor
  • Donald H. Lee
  • Alan C. Jackson
Case Report

DOI: 10.1080/13550280701491131

Cite this article as:
Taylor, S.W., Lee, D.H. & Jackson, A.C. Journal of NeuroVirology (2007) 13: 477. doi:10.1080/13550280701491131


The authors report a patient with herpes simplex encephalitis who presented with magnetic resonance imaging (MRI) lesions exclusively in the frontal lobes, including the bilateral anterior cingulate gyri. She is making a good recovery after therapy with intravenous acyclovir. A similar presentation with a fatal outcome was previously reported by Rose et al (Neurology 42: 1809–1812, 1992). MRI shows temporal lesions in most patients with herpes simplex encephalitis, whereas occasional patients have normal imaging. A high index of suspicion for the diagnosis of herpes simplex encephalitis should be maintained when a patient presents with fever and brain lesions involving extratemporal limbic system structures.


cingulate gyrusencephalitisfrontal lobeherpes simplex virus

Copyright information

© Journal of NeuroVirology, Inc. 2007

Authors and Affiliations

  • Sean W. Taylor
    • 1
  • Donald H. Lee
    • 2
  • Alan C. Jackson
    • 1
    • 3
  1. 1.Department of Medicine (Neurology)Queen’s UniversityKingstonCanada
  2. 2.Departments of Radiology and Nuclear MedicineUniversity of Western OntarioLondonCanada
  3. 3.Health Sciences Centre, GF543WinnipegCanada