Mini-Review—The Rabies Virus

Journal of NeuroVirology

, Volume 11, Issue 1, pp 82-87

First online:

Rabies virus receptors

  • Monique LafonAffiliated withUnité de Neuroimmunologie Virale, Département de Neuroscience, Institut Pasteur Email author 

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Abstract

There is convincing in vitro evidence that the muscular form of the nicotinic acetylcholine receptor (nAChR), the neuronal cell adhesion molecule (NCAM), and the p75 neurotrophin receptor (p75NTR) bind rabies virus and/or facilitate rabies virus entry into cells. Other components of the cell membrane, such as gangliosides, may also participate in the entry of rabies virus. However, little is known of the role of these molecules in vivo. This review proposes a speculative model that accounts for the role of these different molecules in entry and trafficking of rabies virus into the nervous system.

Keywords

nAChR NCAM p75NTR rabies virus