Journal of NeuroVirology

, Volume 11, Issue 1, pp 51–57

A case of a progressive multifocal leukoencephalopathy patient with four different JC virus transcriptional control region rearrangements in cerebrospinal fluid, blood, serum, and urine

Authors

  • Serena Delbue
    • Laboratory of BiologyDon C. Gnocchi Foundation ONLUS, IRCCS
  • Giovanni Sotgiu
    • Clinic of Infectious DiseasesUniversity of Pavia, Policlinico San Matteo
  • Daniela Fumagalli
    • Department of Biomedical Science and TechnologyUniversity of Milan
  • Marilena Valli
    • Laboratory of BiologyDon C. Gnocchi Foundation ONLUS, IRCCS
  • Elisa Borghi
    • Department of Biomedical Science and TechnologyUniversity of Milan
  • Roberta Mancuso
    • Laboratory of BiologyDon C. Gnocchi Foundation ONLUS, IRCCS
  • Enrico Marchioni
    • Neurology DepartmentMondino Hospital
  • Renato Maserati
    • Clinic of Infectious DiseasesPoliclinico San Matteo
    • Laboratory of BiologyDon C. Gnocchi Foundation ONLUS, IRCCS
    • Department of Biomedical Science and TechnologyUniversity of Milan
Article

DOI: 10.1080/13550280590900382

Cite this article as:
Delbue, S., Sotgiu, G., Fumagalli, D. et al. Journal of NeuroVirology (2005) 11: 51. doi:10.1080/13550280590900382

Abstract

JC virus (JCV) is the etiological agent of progressive multifocal leukoencephalopathy (PML), a fatal demyelinating disease of the central nervous system (CNS). During the acquired immunodeficiency syndrome (AIDS) epidemic, it was the cause of the death in up to 8% of AIDS patients. The genomic organization of JCV and, in particular, the hypervariability of the transcriptional control region (TCR), a regulatory noncoding region, are well known. Given that the TCR plays a central role in the viral replication of JCV, a crucial role in the determination of the neurotropism and in the pathogenic capabilities of the virus is also suspected. Here the authors describe a case of PML that did not respond to highly active antiretroviral therapy (HAART) therapy. There was a simultaneous presence of JCV strains with four different TCR structures in urine, peripheral blood cells, serum, and cerebrospinal fluid (CSF) samples. These data confirmed that the presence of the archetype TCR is restricted to urine, while also suggesting that the degree of the rearrangement varies and increases from the peripheral blood to CSF.

Keywords

cerebrospinal fluid (CSF)JC virusprogressive multifocal leukoencephalopathy (PML)transcriptional control region (TCR) rearrangements

Copyright information

© Journal of NeuroVirology, Inc. 2005