Journal of NeuroVirology

, Volume 10, Issue 1, pp 52–56

Cerebrospinal fluid T cells from multiple sclerosis patients recognize autologous Epstein-Barr virus-transformed B cells

Short Communication

DOI: 10.1080/13550280490261671

Cite this article as:
Holmøy, T. & Vartdal, F. Journal of NeuroVirology (2004) 10: 52. doi:10.1080/13550280490261671


The association between multiple sclerosis and Epstein-Barr virus infection could involve Epstein-Barr virus-specific T cells, provided that these T cells get access to the intrathecal compartment. We report that CD4+ T cells from the cerebrospinal fluid of six out of six multiple sclerosis patients, and four out of six patients with other neurological diseases, recognized autologous B cells transformed with Epstein-Barr virus. The cerebrospinal fluid T-cell responses were predominantly HLA-DR restricted. These T cells did not recognize B cells activated through stimulation of CD40 or the inducible autoantigen αB crystalline. These findings support that the immunological response to Epstein-Barr virus could contribute to the pathogenesis of multiple sclerosis.


cerebrospinal fluidEpstein-Barr virusmultiple sclerosisT cells

Copyright information

© Journal of NeuroVirology, Inc. 2004

Authors and Affiliations

  1. 1.Institute of ImmunologyRikshospitalet University HospitalOsloNorway