Journal of NeuroVirology

, Volume 9, Issue 2, pp 222–227

Pathogenesis of human immunodeficiency virus-induced neurological disease

  • Andrew V. Albright
  • Samantha S. Soldan
  • Francisco González-Scarano
Article

DOI: 10.1080/13550280390194073

Cite this article as:
Albright, A.V., Soldan, S.S. & González-Scarano, F. Journal of NeuroVirology (2003) 9: 222. doi:10.1080/13550280390194073

Abstract

Infection of the central nervous system by the type 1 human immunodeficiency virus (HIV-1) commonly results in a number of neurological impairments known, in their most severe form, as HIV-associated dementia (HAD). The persistence of HIV encephalitis (HIVE), the pathological correlate of HAD, in spite of highly active antiretroviral therapy (HAART) underscores the importance of continued research focused on the neurobiology of HIV. To elucidate direct and indirect mechanisms of HIV neuropathogenesis, current investigation is focused on neuroinvasion, HIV-1-mediated mechanisms of neuronal damage and apoptosis, and compartmentalized evolution of virus in the brain. The aim of this review is to provide a selective overview of the most recent research on the neurobiology of HIV, adding only a brief introduction regarding established principles.

Keywords

HIVneuropathogenesisentry

Copyright information

© Journal of NeuroVirology, Inc. 2003

Authors and Affiliations

  • Andrew V. Albright
    • 1
  • Samantha S. Soldan
    • 1
  • Francisco González-Scarano
    • 1
  1. 1.Department of NeurologyHospital of the University of PennsylvaniaPhiladelphiaUSA