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Brain tumors and polyomaviruses

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Abstract

Polyomaviruses, including JC virus (JCV), BK virus (BKV), and simian virus 40 (SV40) have attracted much attention in the past decade due to their repeated isolation from various human tumors, including those originating from the central nervous system (CNS). JCV and BKV are considered to be ubiquitous human pathogens that become reactivated under impaired physiological conditions such as immunosuppression. Productive replication of JCV and BKV induces diseases such as progressive multifocal leukoencephalopathy in the brain and hemorrhagic or nonhemorrhagic cystitis and nephritis in the kidney. JCV DNA sequences have been isolated from a number of human CNS tumors, including medulloblastoma, ependymoma, and a broad range of glial-origin neoplasms. SV40, once believed to be a monkey virus, has now been isolated from a variety of human cancer cells, including mesothelioma, ependymoma, and non-Hodgkin’s lymphoma. In this mini-review, the authors focused their attention on the possible involvement of polyomaviruses, such as JCV, BKV, and SV40, with human brain tumors.

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  1. Center for Neurovirology and Cancer Biology, College of Science and Technology, Temple University, 1900 North 12th Street, 015-96, Room 203, 19122, Philadelphia, PA, USA

    Sidney Croul, Jessica Otte & Kamel Khalili

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  1. Sidney Croul
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  2. Jessica Otte
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  3. Kamel Khalili
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Correspondence to Sidney Croul.

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This work was supported by grants awarded by the NIH to KK.

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Croul, S., Otte, J. & Khalili, K. Brain tumors and polyomaviruses. Journal of NeuroVirology 9, 173–182 (2003). https://doi.org/10.1080/13550280390194055

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