Journal of NeuroVirology

, Volume 9, Issue 1, pp 126–128

Molecular characterization of an Enterovirus 71 causing neurological disease in Germany

  • Johannes Kehle
  • Bernhard Roth
  • Christoph Metzger
  • Artur Pfitzner
  • Gisela Enders
Short Communication

DOI: 10.1080/13550280390173364

Cite this article as:
Kehle, J., Roth, B., Metzger, C. et al. Journal of NeuroVirology (2003) 9: 126. doi:10.1080/13550280390173364

Abstract

Enterovirus 71 (EV71) is mainly known as a cause of hand-foot-and-mouth disease (HFMD) but sometimes associated with neurological disease, even as fatal brainstem encephalitis. In Europe, EV71 infections are extremely rare, in contrast to the worldwide situation. This is the first report of molecular characterization of an EV71 strain isolated in Europe that had caused neurological disease. The german strain is closest related to sublineage B2 strains isolated in the United States, which where mainly associated with neurological disease. Phylogenetic analysis also showed that the strain must have been imported to Germany several years ago, and continues to circulate since then.

Keywords

B2 sublineageEnterovirus 71Europeneurological disease

Copyright information

© Journal of NeuroVirology, Inc. 2003

Authors and Affiliations

  • Johannes Kehle
    • 1
    • 2
  • Bernhard Roth
    • 3
  • Christoph Metzger
    • 1
    • 2
  • Artur Pfitzner
    • 3
  • Gisela Enders
    • 1
    • 2
  1. 1.Laboratory G. Enders and Partner and Institute for VirologyInfectology and EpidemiologyStuttgartGermany
  2. 2.VIROTEST Prof. Enders GmbHStuttgartGermany
  3. 3.Department for General VirologyUniversity of Hohenheim, Institute for GeneticsStuttgartGermany