Journal of NeuroVirology

, Volume 8, Issue 3, pp 158–167

Central nervous system infections in individuals with HIV-1 infection

  • Arunima Mamidi
  • Joseph A. DeSimone
  • Roger J. Pomerantz
Review

DOI: 10.1080/13550280290049723

Cite this article as:
Mamidi, A., DeSimone, J.A. & Pomerantz, R.J. Journal of NeuroVirology (2002) 8: 158. doi:10.1080/13550280290049723

Abstract

Opportunistic infections of the central nervous system (CNS) are common complications of advanced immunodeficiency in individuals with human immunodeficiency virus type 1 (HIV-1) infection. Neurological disease is the first manifestation of acquired immunodeficiency syndrome (AIDS) in 10% to 20% of symptomatic HIV-1 infection. Prompt diagnosis and treatment of such disorders is critical. Also, in the era of highly active antiretroviral therapy (HAART), these disease states have changed in presentation and epidemiology. Therefore, we review the epidemiology, pathogenesis, clinical features, diagnosis, and management of five common central nervous system disorders in individuals with HIV-1 infection: toxoplasma encephalitis, primary central nervous system lymphoma, cryptococcal meningitis, cytomegalovirus encephalitis, and progressive multifocal leukoencephalopathy.

Keywords

human immunodeficiency virus type 1toxoplasma encephalitiscryptococcal meningitiscytomegalovirus encephalitisprogressive multifocal leukoencephalopathy

Copyright information

© Journal of NeuroVirology, Inc. 2002

Authors and Affiliations

  • Arunima Mamidi
    • 1
  • Joseph A. DeSimone
    • 1
  • Roger J. Pomerantz
    • 1
  1. 1.Division of Infectious Diseases, Department of Medicine, Jefferson Medical CollegeThomas Jefferson UniversityPhiladelphiaUSA