Journal of NeuroVirology

, Volume 8, Issue 2, pp 76–85

Murine hepatitis virus—A model for virus-induced CNS demyelination

Review

DOI: 10.1080/13550280290049534

Cite this article as:
Matthews, A.E., Weiss, S.R. & Paterson, Y. Journal of NeuroVirology (2002) 8: 76. doi:10.1080/13550280290049534

Abstract

Most murine hepatitis virus (MHV) strains, as their name suggests, infect the liver. However, several murine strains are tropic for the central nervous system (CNS) and cause encephalitis with subsequent CNS demyelination. The CNS demyelination shares pathological similarities with human CNS demyelinating diseases such as multiple sclerosis (MS). These viruses are, therefore, used to study the role of the immune system in viral clearance from the CNS, in CNS demyelination, and in remyelination. Nevertheless, it is still unclear exactly how MHV induces demyelination and to what extent the immune system plays a role in this pathology. Here we review this field in the context of the immune response to MHV in the liver and the CNS focusing on studies that have been published in the past 5 years.

Keywords

murine hepatitis virusdemyelinationimmune responseCNSmultiple sclerosis

Copyright information

© Taylor & Francis 2002

Authors and Affiliations

  1. 1.Department of MicrobiologyUniversity of Pennsylvania School of MedicinePhiladelphiaUSA
  2. 2.University of PennsylvaniaPhiladelphiaUSA