Journal of NeuroVirology

, Volume 7, Issue 4, pp 307–310

A combination of low-dose chlorpromazine and neutralizing antibodies inhibits the spread of JC virus (JCV) in a tissue culture model: Implications for prophylactic and therapeutic treatment of progressive multifocal leukencephalopathy

Basic Science and Immunobiology Report

DOI: 10.1080/13550280152537157

Cite this article as:
Atwood, W.J. Journal of NeuroVirology (2001) 7: 307. doi:10.1080/13550280152537157

Abstract

The human polyomavirus, JCV, is the etiologic agent of a fatal central nervous system (CNS) demyelinating disease known as progressive multifocal leukoencephalopathy (PML). PML occurs predominantly in immunosuppressed patients and remains an intractable complication in AIDS. To date, there are no effective therapies to treat PML. We previously demonstrated that the neuroleptic drug, chlorpromazine, inhibits the endocytic pathway used by JCV to infect glial cells. In this paper, we demonstrate that nontoxic doses of chlorpromazine are effective at inhibiting JCV multiplication and spread in a tissue culture model. The clinical efficacy of this drug or related compounds in treating PML has not been evaluated

Keywords

central nervous systemdrug therapyJC virusphenothiazinesprogressive multifocal leukoencephalopathy

Copyright information

© Journal of NeuroVirology, Inc. 2001

Authors and Affiliations

  1. 1.Department of Molecular Microbiology and ImmunologyBrown UniversityProvidenceUSA