Journal of NeuroVirology

, Volume 7, Issue 2, pp 155–162

CD4/CXCR4-independent infection of human astrocytes by a T-tropic strain of HIV-1


  • Becky Schweighardt
    • Department of Molecular Microbiology and ImmunologyBrown University
  • Joseph T. C. Shieh
    • Department of NeurologyUniversity of Pennsylvania Medical Center
  • Walter J. Atwood
    • Department of Molecular Microbiology and ImmunologyBrown University
Short Communication

DOI: 10.1080/13550280152058816

Cite this article as:
Schweighardt, B., Shieh, J.T.C. & Atwood, W.J. Journal of NeuroVirology (2001) 7: 155. doi:10.1080/13550280152058816


HIV-1 establishes a low-level persistent infection in astrocytes. In this study, we studied the susceptibility of a human astrocyte cell line (SVG-A) to infection with luciferase expressing reporter viruses pseudotyped with envelopes derived from five isolates of HIV-1. SVG-A cells were susceptible to infection by a T-cell tropic isolate and the infection was both CD4 and CXCR4 independent. These data confirm the susceptibility of astrocytes to infection with T-tropic strains of HIV-1 and suggest a novel mechanism by which T-tropic strains of HIV can infect cells.

Copyright information

© Journal of NeuroVirology, Inc. 2001