Journal of NeuroVirology

, Volume 7, Issue 1, pp 66–71

Acceleration of HIV dementia with methamphetamine and cocaine

  • Avindra Nath
  • William F. Maragos
  • Malcolm J. Avison
  • Frederick A. Schmitt
  • Joseph R. Berger
Case Report

DOI: 10.1080/135502801300069737

Cite this article as:
Nath, A., Maragos, W.F., Avison, M.J. et al. Journal of NeuroVirology (2001) 7: 66. doi:10.1080/135502801300069737

Abstract

We report a patient with rapidly accelerating HIV dementia accompanied by seizures and an unusual movement disorder despite highly potent antiretroviral therapy. This clinical constellation was associated with the non-parenteral use of methamphetamine and cocaine. Fractional enhancement time on post contrast magnetic resonance imaging studies revealed a progressive breakdown of the blood brain barrier particularly in the basal ganglia. The movement disorder but not the dementia responded to a combination of dopamine replacement and anticholinergic therapy. While the movement disorder may have been unmasked by concomitant anticonvulsant therapy, we suggestin this instance, that prior drug abuse synergized with HIV to cause a domino effect on cerebral function. Careful attention and analysis to histories of remote non-injecting drug abuse may help substantiate our hypothesis.

Keywords

HIV brain AIDS cocaine methamphetamine 

Copyright information

© Taylor & Francis Ltd 2001

Authors and Affiliations

  • Avindra Nath
    • 1
    • 2
  • William F. Maragos
    • 1
    • 3
  • Malcolm J. Avison
    • 1
  • Frederick A. Schmitt
    • 1
  • Joseph R. Berger
    • 1
  1. 1.Department of NeurologyUniversity of KentuckyLexingtonUSA
  2. 2.Department of Microbiology and ImmunologyUniversity of KentuckyLexingtonUSA
  3. 3.Anatomy and NeurobiologyUniversity of KentuckyLexingtonUSA