Neurotoxicity Research

, Volume 4, Issue 1, pp 77–81

The biochemical basis of Parkinson's disease: The role of catecholamineo-quinones: A review-discussion

  • John Smythies
  • Angela De Iuliis
  • Lucia Zanatta
  • Lauro Galzigna
Article

DOI: 10.1080/10298420290007655

Cite this article as:
Smythies, J., De Iuliis, A., Zanatta, L. et al. neurotox res (2002) 4: 77. doi:10.1080/10298420290007655

Abstract

This paper reviews the possible role of catecholamineo-quinones (OQs) in the genesis of Parkinson's disease (PD). This disease is characterized by damage caused to the pigmented catecholaminergic cells in various areas of the brain. The pigment involved is neuromelanin that is the end product of catecholamine oxidation by theo-quinone route. Evidence is presented regarding the overproduction in PD of these catecholamine OQs that damage the electron chain in the mitochondria leading to cell death. The roles of glutathione S-transferase and reactive oxygen species in this are also surveyed. A review of all known biochemical properties of theseo-quinones is included. The hypothesis is put forward that an important factor in the genesis of PD may be the overload by environmental toxins of enzymes such as glutathioneS-transferase that also detoxify catecholamine OQs.

Keywords

Catecholamineo-quinonesParkinson's diseaseNeuromelaninGlutathioneReactive oxygen species

Abbreviations

ACh

Acetylcholine

AChe

Acetylcholine esterase

ATP

Adenosine triphosphate

CAT

Catalase

DA

Dopamine

DAQs

Dopamineo-quinones

GSH

Glutathione

GSHpx

Glutathione peroxidase

GSSG

Oxidized glutathione

HO-1

Hemeoxygenase-1

LC

Locus coeruleus

MTP

Mitochondrial transition pore

OQs

o-quinones

PD

Parkinson's disease

PGH

Prostaglandin H

NADH

Nicotine adenine dinucleotide

ROS

Reactive oxygen species

SOD

Superoxide dismutase

SNpc

Substantia nigra pars compacta

TNF

Tumor necrosis factor

VTA

Ventral tegmental area

Copyright information

© Taylor & Francis Ltd 2002

Authors and Affiliations

  • John Smythies
    • 1
    • 3
  • Angela De Iuliis
    • 2
  • Lucia Zanatta
    • 2
  • Lauro Galzigna
    • 2
  1. 1.Center for Brain and Cognition, Department of PsychologyUniversity of CaliforniaLa JollaUSA
  2. 2.Department of Diagnostics, Medical SchoolUniversity of PadovaPadovaItaly
  3. 3.Department of NeuropsychiatryInstitute of NeurologyLondonUK