Journal of Public Health Policy

, Volume 30, Issue 2, pp 127–143

Medication-associated diethylene glycol mass poisoning: A review and discussion on the origin of contamination

Authors

    • Division of Environmental Hazards and Health Effects, National Center for Environmental Health, Centers for Disease Control and Prevention
  • Carol S Rubin
    • Division of Environmental Hazards and Health Effects, National Center for Environmental Health, Centers for Disease Control and Prevention
  • Dorothy Miller
    • United States Food and Drug Administration
  • Dana Barr
    • Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention
  • Michael A McGeehin
    • Division of Environmental Hazards and Health Effects, National Center for Environmental Health, Centers for Disease Control and Prevention
Original Article

DOI: 10.1057/jphp.2009.2

Cite this article as:
Schier, J., Rubin, C., Miller, D. et al. J Public Health Pol (2009) 30: 127. doi:10.1057/jphp.2009.2

Abstract

Diethylene glycol (DEG), an extremely toxic chemical, has been implicated as the etiologic agent in at least 12 medication-associated mass poisonings over the last 70 years. Why DEG mass poisonings occur remains unclear. Most reports do not contain detailed reports of trace-back investigations into the etiology. The authors, therefore, conducted a systematic literature review on potential etiologies of these mass poisonings. The current available evidence suggests that substitution of DEG or DEG-containing compounds for pharmaceutical ingredients results from: (1) deception as to the true nature of certain ingredients by persons at some point in the pharmaceutical manufacturing process, and (2) failure to adhere to standardized quality control procedures in manufacturing pharmaceutical products intended for consumers. We discuss existing guidelines and new recommendations for prevention of these incidents.

Keywords

diethylene glycolmass poisoningpoisoning

Copyright information

© Palgrave Macmillan 2009