Shear stress effects on plant cell suspension cultures in a rotating wall vessel bioreactor
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- Sun, X. & Linden, J. J Ind Microbiol Biotech (1999) 22: 44. doi:10.1038/sj.jim.2900600
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A rotating wall vessel, designed for growth of mammalian cells under microgravity, was used to study shear effects on Taxus cuspidata plant suspension cell cultures. Shear stress, as quantified by defined shear fields of Couette viscometers, improved specific cell growth rates and was detrimental to volumetric product formation rates.