Abstract
Effects of ischemia on the content of a ulinastatin (UT)-like substance in the murine cerebral cortex and hippocampus were studied. At 24 h post-ischemia, a significant (p < 0.05) decrease in the content of UT-like substance in the hippocampus but not the cerebral cortex and a concurrent increase in the activity of μ-calpain were observed. In in vitro experiments, a decrease was registered in the content of UT-like substance in the hippocampus in the presence of calcium. This decrease was inhibited by both EDTA and calpastatin treatments. These results implicate the destruction of UT-like substance by μ-calpain in the ischemic hippocampus.
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Shikimi, T., Gonda, T., Takahashi, M. et al. Ischemia Induces a Reduction in the Content of Ulinastatin-Like Substance in the Murine Hippocampus. Neurochem Res 23, 69–72 (1998). https://doi.org/10.1023/A:1022453504527
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DOI: https://doi.org/10.1023/A:1022453504527