Continuous On-Chip Micropumping for Microneedle Enhanced Drug Delivery
Rent the article at a discountRent now
* Final gross prices may vary according to local VAT.Get Access
Microneedles are promising microfabricated devices for minimally invasive drug delivery applications. Needles can be integrated into a variety of devices. However, any portable drug delivery device with integrated microneedles will need an equally compact means to deliver therapeutics. This work presents microneedles integrated with an on-chip MEMS positive displacement micropump for continuous drug delivery applications. The generation and collapse of thermally generated bubbles with flow rectified by directional check valves are used to achieve net pumping through the device. Visualization methods have observed net flow rates of water out of a microneedle at approximately 2.0 nl/s with a pressure of 3.9 kPa. In addition, continuous pumping was achieved for more than 6 hours with the heaters actuating for over 18 hours (15,000 cycles) without failing.
- Brazzle, J., Papautsky, I., Frazier, A.B. (1999) IEEE Engineering in Medicine and Biology Magazine. IEEE 18: pp. 53-58
- J. Brazzle, D. Bartholomeusz, R. Davies, J. Andrade, R.A. Van Wageman, and A.B. Frazier, Proceedings 2000 Solid State Sensor and Actuator Workshop, Hilton Head, S.C., 199–202 (June, 2000).
- J. Chen and K.D. Wise, Solid State Sensor and Actuator Workshop, Hilton Head, S.C., 256–259 (June, 1994).
- deshmukh, A.A. (2001) Continuous Microfuidic Mixing Using Pulsatile Micropumping. University of California, Berkeley
- A.A. Deshmukh, D. Liepmann, and A.P. Pisano, Proceedings 2000 Solid State Sensor and Actuator Workshop, Hilton Head, S.C., 73–76 (June, 2000).
- Evans, J.D. (1999) Planar Microfuidics: Towards Large Scale Integration of Channels, Pumps, Valves, and Fluid Mixers in Microelectro-mechanical Systems (MEMS). University of California, Berkeley, CA
- Forster, F., Bardell, R., Afromowitz, M., Sharma, N., Blanchard, A. (1995) Proceedings of the ASME Fluids Engineering Division 234: pp. 39-44
- Gravesen, P., Branebjerg, J., Jensen, O.S. (1993) J. Micromech. Microeng. 3: pp. 168-182
- C. Grosjean and Y.C. Tai, 1999 International Conference on Solid-State Sensors and Actuators (Transducers'99), Sendai, Japan (June, 1999).
- S. Henry, D.V. McAllister, M. Allen, and M. Prausnitz, Proceedings of the IEEE Eleventh Annual International Workshop on MEMS, Heidelberg, Germany, 494–498 (January, 1998).
- Kost, J. (1993) J. Controlled Release 24: pp. 247-255
- K.S. Lebouitz and A.P. Pisano, Proceedings Microstructures and Microfabrication Systems IV, 194th meeting of the Electrochemical Society, Boston, MA (Nov. 1–6, 1998).
- Liepmann, D., Pisano, A., Sage, B. (1999) Diabetes Technology and Therapeutics 1: pp. 469-476
- L. Lin, A.P. Pisano, and R.S. Muller, Proceedings 7th International Conference on Solid State Sensors and Actuators (Transducers'93), Yokohama, Japan, 237–240 (1993).
- L. Lin, A.P. Pisano, and A.P Lee, 1991 International Conference on Solid-State Sensors and Actuators. Digest of Technical Papers (Transducers'91), 1041–1044 (1991).
- D.V. McAllister, E Cros, S.P. Davis, L.M. Matta, M.R. Prausnitz, and M.G. Allen, Proceedings 10th International Conference on Solid State Sensors and Actuators (Transducers'99), 1098–1101 (1999).
- A. Olsson, G. Stemme, and E. Stemme, Proceedings IEEE Workshop On Micro Electro Mechanical Systems (MEMS'96), 378–383 (Feb., 1996).
- I.E. Papautsky, J.D. Brazzle, H. Swerdlow, and A.B. Frazier, IEEE International Conference on Engineering in Medicine and Biology Conference, Chicago, IL (October, 1997).
- Prausnitz, M. R. In: Bemer, B., Dinh, S.M. eds. (1995) Electronically controled Drug Delivery. CRC Press, Boca Raton, FL
- Smith, E.W, Malbach, H.L. (1995) Percutaneous Penetration Enhancers. CRC Press, Boca Raton, FL
- B. Stoeber and D. Liepmann, Proceedings of the 1st IEEE-EMBS Special Topic Conference on Microtechnology in Medicine & Biology, Lyon (2000a).
- Stoeber, B., Liepmann, D. (2000) Proceedings of the ASME MEMS Division, 2000 IMECE 1: pp. 355-359
- P. Stupar and A.P. Pisano, Proceedings 11th International Conference on Solid State Sensors and Actuators (Transducers'01), Munich, Germany (2001).
- N. Talbot and A.P. Pisano, Proceedings 1998 Solid State Sensor and Actuator Workshop, Hilton Head S.C., 265–268 (June, 1998).
- N. Talbot, Polysilicon Micromolding of Closed-Flow Passages for the Fabrication of Multifunctional Microneedles (Ph.D. Thesis, University of California, Berkeley, CA, 1999).
- J.H. Tsai and L. Lin, Late News Poster Session Supplemental Digest of Solid-State Sensor and Actuator Workshop, Hilton Head S.C., 13–14 (2000).
- J.D. Zahn, A.A. Deshmukh, A.P. Pisano, and D. Liepmann, 14th Annual IEEE International MEMS-01 Conference, Interlaken, Switzerland, (January 21–25, 2001).
- Zahn, J.D., Talbot, N.H., Liepmann, D., Pisano, A.P. (2000) Biomedical Microdevices 2: pp. 295-303
- Continuous On-Chip Micropumping for Microneedle Enhanced Drug Delivery
Volume 6, Issue 3 , pp 183-190
- Cover Date
- Print ISSN
- Online ISSN
- Kluwer Academic Publishers
- Additional Links
- drug delivery
- Industry Sectors
- Author Affiliations
- 1. Department of Bioengineering, Pennsylvania State University and Berkeley Sensor and Actuator Center, University of California at Berkeley and Department of Bioengineering, University of California at Berkeley, U.S.A
- 2. Berkeley Sensor and Actuator Center, University of California at Berkeley and Department of Mechanical Engineering, 497 Cory Hall, University of California at Berkeley, Berkeley, CA, 94720-1774, U.S.A