Skip to main content
SpringerLink
Log in

Effect of Ivermectin on Function of Liver Macrophages

  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Ivermectin had no effect on phagocytic function of liver macrophages, but blocked LPS-induced secretion of tumor necrosis factor, NO, prostaglandin E2, and increase of intracellular concentration of Ca2+. These inhibitory effects were observed only in the presence of chlorine ions in the extracellular medium, which attested to involvement of glycine-dependent chlorine channels.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

REFERENCES

  1. G. R. Dawson, K. A. Wafford, A. Smith, et al.,J. Pharmacol. Exp. The., 295, No. 3, 1051-1060 (2000).

    Google Scholar 

  2. M. Froh, R. G. Thurman, and M. D. Wheeler, Am. J. Physiol. Gastrointest. Liver Physiol., 283, No. 4, G856-G863 (2002).

    Google Scholar 

  3. K. L. Goa, D. McTavish, and S. P. Clissold, Drugs, 42, 640-568 (1991).

    Google Scholar 

  4. L. C. Green, D. A. Wagner, J. Glogowsky, et al., Anal. Biochem., 126, 131-138 (1982).

    Google Scholar 

  5. M. Hirose, M. Tomono, M. Takeuchi, et al., Acta Hepatol. Jap., 28, 1327-1330 (1987).

    Google Scholar 

  6. P. Schemmer, N. Enomoto, B. U. Bradford, et al., Am. J. Physiol. Gastrointest. Liver Physiol., 280, G1076-G1082 (2001).

    Google Scholar 

  7. Q. Shang, J. L. Haddrill, and J. W. Lynch, J. Biol. Chem., 276, No. 16, 12,556-12,564 (2001).

    Google Scholar 

  8. G. L. Su, Am. J. Physiol. Gastrointest. Liver Physiol., 283, No. 2, G256-G265 (2002).

    Google Scholar 

  9. D. K. Vassilatis, J. P. Arena, R. H. Plasterk, et al., J. Biol. Chem., 272, No. 52, 33,167-33,174 (1997).

    Google Scholar 

  10. A. V. Victorov, E. R. Abril, C. E. Hamlin, et al., Cells of the Hepatic Sinusoid, Kupffer Cell Foundation, Eds. E. Wisse et al. (1991), Vol. 3, pp. 449-452.

  11. A. V. Victorov and J. B. Hoek, Biochim. Biophys. Res. Commun., 215, No. 2, 691-697 (1995).

    Google Scholar 

  12. M. D. Wheeler, K. Ikejima, N. Enomoto, et al., Cell. Mol. Life Sci., 56, No. 9-10, 843-856 (1999).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Central Institute of Epidemiology, Ministry of Health of Russian Federation, Moscow

    A. V. Viktorov & V. A. Yurkiv

Authors
  1. A. V. Viktorov
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. V. A. Yurkiv
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to A. V. Viktorov.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Viktorov, A.V., Yurkiv, V.A. Effect of Ivermectin on Function of Liver Macrophages. Bulletin of Experimental Biology and Medicine 136, 569–571 (2003). https://doi.org/10.1023/B:BEBM.0000020206.23474.e9

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/B:BEBM.0000020206.23474.e9

Search

Navigation