Abstract
Objective: To determine the long-term outcome of resected choroid plexus papillomas (CPPs).
Methods: Medical records and histologic specimens were reviewed for 41 patients (19 male, 22 female; median age, 36 years; range, 6 months to 74 years) with CPP seen between 1974 and 2000. Tumor locations were as follows: 76%, fourth ventricle; 17%, lateral ventricle, and 7%, third ventricle. Fifty-six percent had a gross total resection (GTR) and 44% had a subtotal resection (STR). Median follow-up was 6.5 years.
Results: Five-year local control, distant brain control, and overall survival were 84%, 92%, and 97%, respectively. Comparison of GTR and STR at 5 years showed a significant increase in local control (100% vs. 68%; P = 0.04) but not in overall survival (100% vs. 94%). Even after STR, only 50% of patients required a subsequent resection for recurrence. Addition of radiation therapy to initial STR did not seem to influence outcomes. At first relapse, GTR was accomplished in 1 patient, and only STR was accomplished in the others. Addition of radiation therapy to STR in our study led to disease control in half the patients treated, and STR alone led to disease control in only a quarter of the patients. Second relapses were treated palliatively with radiation therapy.
Conclusions: Surgical resection is the treatment of choice for CPPs. After initial STR, reoperations for recurrence are required only half the time. Therefore, there seems to be no role for radiation therapy after initial STR. For STRs at first relapse, local control outcome is poor.
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References
Hammack JE: Choroid plexus papilloma and carcinoma. In: Raghavan D, Brecher ML, Johnson DH, Meropol NJ, Moots PL, Thigpen JT (eds) Textbook of Uncommon Cancer, 2nd edn., John Wiley & Sons, Chichester, 1999, pp 335-340
McGirr SJ, Ebersold MJ, Scheithauer BW, Quast LM, Shaw EG: Choroid plexus papillomas: long-term follow-up results in a surgically treated series. J Neurosurg 69: 843–849, 1988
Ellenbogen RG, Winston KR, Kupsky WJ: Tumors of the choroid plexus in children. Neurosurgery 25: 327–335, 1989
Guidetti B, Spallone A: The surgical treatment of choroid plexus papillomas: the results of 27 years experience. Neurosurg Rev 4: 129–137, 1981
Palazzi M, Di Marco A, Campostrini F, Grandinetti A, Bontempini L: The role of radiotherapy in the management of choroid plexus neoplasms. Tumori 75: 463–469, 1989
Sarkar C, Sharma MC, Gaikwad S, Sharma C, Singh VP: Choroid plexus papilloma: a clinicopathological study of 23 cases. Surg Neurol 52: 37–39, 1999
Tacconi L, Delfini R, Cantore G: Choroid plexus papillomas: consideration of a surgical series of 33 cases. Acta Neurochir 138: 802–810, 1996
Talacchi A, De Micheli E, Lombardo C, Turazzi S, Bricolo A: Choroid plexus papilloma of the cerebellopontine angle: a twelve patient series. Surg Neurol 51: 621–629, 1999
Kaplan EL, Meier P: Nonparametric estimation from incomplete observations. J Am Stat Assoc 53: 457–481, 1958
Mantel N: Evaluation of survival data and two new rank order statistics arising in its consideration. Cancer Chemother Rep 50: 163–170, 1966
Davis LE, Cushing H: Papillomas of the choroid plexus: with the report of 6 cases. Arch Neurol Psychiatry 13: 681–710, 1925
Berger C, Thiesse P, Lellouch-Tubiana A, Kalifa C, Pierre-Kahn A, Bouffet E: Choroid plexus carcinomas in childhood: clinical features and prognostic factors. Neurosurgery 42: 470–475, 1998
Chow E, Reardon DA, Shah AB, Jenkins JJ, Langston J, Heideman RL, Sanford RA, Kun LE, Merchant TE: Pediatric choroid plexus neoplasms. Int J Radiat Oncol Biol Phys 44: 249–254, 1999
Kawano H, Hayashi M, Kobayashi H, Handa Y, Kubota T: Choroid plexus papilloma in early infants. Zentralbl Neurochir 50: 171–175, 1989
Lena G, Genitori L, Molina J, Legatte JR, Choux M: Choroid plexus tumours in children: review of 24 cases. Acta Neurochir 106: 68–72, 1990
McEvoy AW, Harding BN, Phipps KP, Ellison DW, Elsmore AJ, Thompson D, Harkness W, Hayward RD: Management of choroid plexus tumours in children: 20 years experience at a single neurosurgical centre. Pediatr Neurosurg 32: 192–199, 2000
Nagib MG, O'Fallon MT: Lateral ventricle choroid plexus papilloma in childhood: management and complications. Surg Neurol 54: 366–372, 2000
Pascual-Castroviejo I, Villarejo F, Perez-Higueras A, Morales C, Pascual-Pascual SI: Childhood choroid plexus neoplasms: a study of 14 cases less than 2 years old. Eur J Pediatr 140: 51–56, 1983
Pencalet P, Sainte-Rose C, Lellouch-Tubiana A, Kalifa C, Brunelle F, Sgouros S, Meyer P, Cinalli G, Zerah M, Pierre-Kahn A, Renier D: Papillomas and carcinomas of the choroid plexus in children. J Neurosurg 88: 521–528, 1998
Raimondi AJ, Gutierrez FA: Diagnosis and surgical treatment of choroid plexus papillomas. Childs Brain 1: 81–115, 1975
Sharma R, Rout D, Gupta AK, Radhakrishnan VV: Choroid plexus papillomas. Br J Neurosurg 8: 169–177, 1994
Spallone A, Pastore FS, Giuffre R, Guidetti B: Choroid plexus papillomas in infancy and childhood. Childs Nerv Syst 6: 71–74, 1990
Levy ML, Goldfarb A, Hyder DJ, Gonzales-Gomez I, Nelson M, Gilles FH, McComb JG: Choroid plexus tumors in children: significance of stromal invasion. Neurosurgery 48: 303–309, 2001
Tomlinson F, Scheithauer B, Burger P, Hammack J, Hu T: Choroid plexus neoplasia: an immunochemical, flow cytometric & proliferation marker study. Brain Pathol 4: 437, 1994 (abstract)
Carrea R, Polak M: Preoperative radiotherapy in the management of posterior fossa choroid plexus papillomas. Childs Brain 3: 12–24, 1977
Duke BJ, Kindt GW, Breeze RE: Pineal region choroid plexus papilloma treated with stereotactic radiosurgery: a case study. Comput Aided Surg 2: 135–138, 1997
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Krishnan, S., Brown, P.D., Scheithauer, B.W. et al. Choroid Plexus Papillomas: A Single Institutional Experience. J Neurooncol 68, 49–55 (2004). https://doi.org/10.1023/B:NEON.0000024745.06073.07
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DOI: https://doi.org/10.1023/B:NEON.0000024745.06073.07