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Antigenic Differences between apo-B in Native and Circulating Modified Low-Density Lipoproteins

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Abstract

The state of apo-B in native and circulating modified low-density lipoproteins was studied by solid-phase enzyme immunoassay. We studied the interaction of these particles with monoclonal antibodies to apo-B of low-density lipoproteins. Native and circulating modified low-density lipoproteins had different affinity for the studied antigens. Our results illustrate conformational changes in apo-B of circulating modified low-density lipoproteins compared to native low-density lipoproteins. These changes probably contribute to increased accumulation of particles in vascular cells and their transformation into foam cells giving way to atherosclerotic vascular lesions.

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Authors and Affiliations

  1. Laboratory for Mechanisms of Atherogenesis, Institute of Experimental Cardiology, Russian Research-and-Production Complex for Cardiology, Russian Ministry of Health; Institute of Atherosclerosis, Russian Academy of Natural Sciences, Moscow

    I. V. Suprun, A. A. Melnichenko, E. V. Yanushevskaya, T. N. Vlasik, I. A. Sobenin, O. M. Panasenko & A. N. Orekhov

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  1. I. V. Suprun
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  2. A. A. Melnichenko
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  3. E. V. Yanushevskaya
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  4. T. N. Vlasik
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  5. I. A. Sobenin
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  6. O. M. Panasenko
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  7. A. N. Orekhov
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Suprun, I.V., Melnichenko, A.A., Yanushevskaya, E.V. et al. Antigenic Differences between apo-B in Native and Circulating Modified Low-Density Lipoproteins. Bulletin of Experimental Biology and Medicine 138, 42–44 (2004). https://doi.org/10.1023/B:BEBM.0000046934.76907.9d

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  • DOI: https://doi.org/10.1023/B:BEBM.0000046934.76907.9d

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