Abstract
The state of apo-B in native and circulating modified low-density lipoproteins was studied by solid-phase enzyme immunoassay. We studied the interaction of these particles with monoclonal antibodies to apo-B of low-density lipoproteins. Native and circulating modified low-density lipoproteins had different affinity for the studied antigens. Our results illustrate conformational changes in apo-B of circulating modified low-density lipoproteins compared to native low-density lipoproteins. These changes probably contribute to increased accumulation of particles in vascular cells and their transformation into foam cells giving way to atherosclerotic vascular lesions.
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REFERENCES
V. V. Tertov, V. V. Kaplun, I. A. Sobenin, et al., Byull. Eksp. Biol. Med., 122, No. 7, 37–39 (1996).
E. V. Yanushevskaya, N. V. Valentinova, N. V. Medvedeva, et al., Angiol. Sosud. Khir., 5, Appl., 241–251.
A. N. Orekhov, V. V. Tertov, D. N. Mukhin, et al., Biochem. Biophys. Res. Commun., 162, 206–211 (1989).
A. N. Orekhov, V. V. Tertov, I. A. Sobenin, et al., J. Lipid Res., 33, 805–807 (1992).
V. V. Tertov, G. Bittolo-Bon, I. A. Sobenin, et al., Exp. Mol. Biol., 62, 166–172 (1995).
V. V. Tertov and A. N. Orekhov, Exp. Mol. Pathol., 64, 127 (1997).
V. V. Tertov, A. N. Orekhov, I. A. Sobenin, et al., J. Lipid Res., 34, 365–375 (1993).
V. V. Tertov, I. A. Sobenin, Z. A. Gabbazov, et al., Lab. Invest., 67, 665–675 (1992).
V. V. Tertov, I. A. Sobenin, A. G. Tonevitsky, et al., Biochem. Biophys. Res. Commun., 167, 1122–1127 (1990).
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Suprun, I.V., Melnichenko, A.A., Yanushevskaya, E.V. et al. Antigenic Differences between apo-B in Native and Circulating Modified Low-Density Lipoproteins. Bulletin of Experimental Biology and Medicine 138, 42–44 (2004). https://doi.org/10.1023/B:BEBM.0000046934.76907.9d
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DOI: https://doi.org/10.1023/B:BEBM.0000046934.76907.9d