Journal of Mammary Gland Biology and Neoplasia

, Volume 2, Issue 3, pp 299–310

The Tammar Wallaby: A Model to Study Putative Autocrine-Induced Changes in Milk Composition

  • Kevin Nicholas
  • Kaylene Simpson
  • Michael Wilson
  • Josephine Trott
  • Denis Shaw
Article

DOI: 10.1023/A:1026392623090

Cite this article as:
Nicholas, K., Simpson, K., Wilson, M. et al. J Mammary Gland Biol Neoplasia (1997) 2: 299. doi:10.1023/A:1026392623090

Abstract

The marsupial newborn is immature and the mother has the capacity to alter milk composition significantly during lactation, presumably to meet the nutritional requirements of the developing young. Furthermore, macropodid marsupials may practice asynchronous concurrent lactation (ACL)7whereby the mother provides milk which differs in all the major components from adjacent mammary glands for two young of different ages. This phenomenon suggests that local regulation of mammary function, in addition to endocrine stimuli, is likely to be important for controlling milk composition. This paper explores the possibility that changes in sucking patterns of the young represent the first step in a mechanism to signal the mammary gland for putative autocrine-induced changes in milk composition.

Marsupialmilk protein compositionasynchronous concurrent lactationsucking patternsautocrine regulationmilk protein genes

Copyright information

© Plenum Publishing Corporation 1997

Authors and Affiliations

  • Kevin Nicholas
    • 1
  • Kaylene Simpson
    • 1
    • 2
  • Michael Wilson
    • 1
    • 3
  • Josephine Trott
    • 1
    • 4
  • Denis Shaw
    • 5
  1. 1.Division of Molecular Biology and GeneticsVictorian Institute of Animal ScienceAttwoodAustralia
  2. 2.School of AgricultureLaTrobe UniversityBundooraAustralia
  3. 3.Human Immunogenetics LaboratoryImperial Cancer Research FundLondonUnited Kingdom
  4. 4.Department of ZoologyMelbourne UniversityParkvilleAustralia
  5. 5.Protein Biochemistry GroupJohn Curtin School of Medical Research, Australian National UniversityAustralian Capital TerritoryAustralia