Bulletin of Experimental Biology and Medicine

, Volume 136, Issue 1, pp 73–75

Relationship between Glutathione S-Transferase P1 Polymorphism and Bronchial Asthma and Atopic Dermatitis

Authors

    • Siberian Division of the Russian Academy of Medical SciencesInstitute of Molecular Biology and Biophysics
  • V. A. Vavilin
    • Siberian Division of the Russian Academy of Medical SciencesInstitute of Molecular Biology and Biophysics
    • Novosibirsk State Medical Academy
    • Municipal Children's Hospital No. 1
  • A. A. Lyapunova
    • Siberian Division of the Russian Academy of Medical SciencesInstitute of Molecular Biology and Biophysics
    • Novosibirsk State Medical Academy
    • Municipal Children's Hospital No. 1
  • S. I. Makarova
    • Siberian Division of the Russian Academy of Medical SciencesInstitute of Molecular Biology and Biophysics
    • Novosibirsk State Medical Academy
    • Municipal Children's Hospital No. 1
  • V. V. Lyakhovich
    • Siberian Division of the Russian Academy of Medical SciencesInstitute of Molecular Biology and Biophysics
    • Novosibirsk State Medical Academy
    • Municipal Children's Hospital No. 1
  • L. F. Kaznacheeva
    • Siberian Division of the Russian Academy of Medical SciencesInstitute of Molecular Biology and Biophysics
    • Novosibirsk State Medical Academy
    • Municipal Children's Hospital No. 1
  • N. A. Manankin
    • Siberian Division of the Russian Academy of Medical SciencesInstitute of Molecular Biology and Biophysics
    • Novosibirsk State Medical Academy
    • Municipal Children's Hospital No. 1
  • O. A. Batychko
    • Siberian Division of the Russian Academy of Medical SciencesInstitute of Molecular Biology and Biophysics
    • Novosibirsk State Medical Academy
    • Municipal Children's Hospital No. 1
  • S. M. Gavalov
    • Siberian Division of the Russian Academy of Medical SciencesInstitute of Molecular Biology and Biophysics
    • Novosibirsk State Medical Academy
    • Municipal Children's Hospital No. 1
Article

DOI: 10.1023/A:1026001216033

Cite this article as:
Safronova, O.G., Vavilin, V.A., Lyapunova, A.A. et al. Bulletin of Experimental Biology and Medicine (2003) 136: 73. doi:10.1023/A:1026001216033

Abstract

We determined the prevalence of GSTP1-Ile105 and GSTP1-Val105 alleles in patients with bronchial asthma and atopic dermatitis and healthy children of 2 groups (randomized and nonatopic control). The GSTP1-Ile105/Val105 genotype determines the resistance to atopic dermatitis (odds ratio=0.51; 95% confidence interval: 0.28-0.92; p=0.023). However, both homozygotes are at high risk of developing atopic dermatitis (near-significant differences).

bronchial asthmaatopic dermatitisxenobioticsglutathione S-transferase P1 polymorphismpredisposition

Copyright information

© Plenum Publishing Corporation 2003