Article

Bulletin of Experimental Biology and Medicine

, Volume 136, Issue 1, pp 73-75

Relationship between Glutathione S-Transferase P1 Polymorphism and Bronchial Asthma and Atopic Dermatitis

  • O. G. SafronovaAffiliated withSiberian Division of the Russian Academy of Medical Sciences, Institute of Molecular Biology and Biophysics Email author 
  • , V. A. VavilinAffiliated withSiberian Division of the Russian Academy of Medical Sciences, Institute of Molecular Biology and BiophysicsNovosibirsk State Medical AcademyMunicipal Children's Hospital No. 1
  • , A. A. LyapunovaAffiliated withSiberian Division of the Russian Academy of Medical Sciences, Institute of Molecular Biology and BiophysicsNovosibirsk State Medical AcademyMunicipal Children's Hospital No. 1
  • , S. I. MakarovaAffiliated withSiberian Division of the Russian Academy of Medical Sciences, Institute of Molecular Biology and BiophysicsNovosibirsk State Medical AcademyMunicipal Children's Hospital No. 1
  • , V. V. LyakhovichAffiliated withSiberian Division of the Russian Academy of Medical Sciences, Institute of Molecular Biology and BiophysicsNovosibirsk State Medical AcademyMunicipal Children's Hospital No. 1
  • , L. F. KaznacheevaAffiliated withSiberian Division of the Russian Academy of Medical Sciences, Institute of Molecular Biology and BiophysicsNovosibirsk State Medical AcademyMunicipal Children's Hospital No. 1
  • , N. A. ManankinAffiliated withSiberian Division of the Russian Academy of Medical Sciences, Institute of Molecular Biology and BiophysicsNovosibirsk State Medical AcademyMunicipal Children's Hospital No. 1
  • , O. A. BatychkoAffiliated withSiberian Division of the Russian Academy of Medical Sciences, Institute of Molecular Biology and BiophysicsNovosibirsk State Medical AcademyMunicipal Children's Hospital No. 1
  • , S. M. GavalovAffiliated withSiberian Division of the Russian Academy of Medical Sciences, Institute of Molecular Biology and BiophysicsNovosibirsk State Medical AcademyMunicipal Children's Hospital No. 1

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Abstract

We determined the prevalence of GSTP1-Ile105 and GSTP1-Val105 alleles in patients with bronchial asthma and atopic dermatitis and healthy children of 2 groups (randomized and nonatopic control). The GSTP1-Ile105/Val105 genotype determines the resistance to atopic dermatitis (odds ratio=0.51; 95% confidence interval: 0.28-0.92; p=0.023). However, both homozygotes are at high risk of developing atopic dermatitis (near-significant differences).

bronchial asthma atopic dermatitis xenobiotics glutathione S-transferase P1 polymorphism predisposition